{"id":"W4413920704","doi":"10.1200/po-25-00588","title":"Reply to: Germline and Somatic <i>BRCA1/2</i> Mutations in Breast Cancer Treatment Strategies","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Germline; Somatic cell; Germline mutation; Breast cancer; Oncology; Genetics; Medicine; Biology; Mutation; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280925,0.0001686307,0.0004651851,0.0002917321,0.00006061937,0.00001829809,0.00006532767,0.00009792051,0.0001902012],"category_scores_gemma":[0.00005092463,0.000133197,0.00004385468,0.0003871729,0.00008935769,0.0001145785,0.00005164979,0.0001213815,0.00001639971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008236115,"about_ca_system_score_gemma":0.0007138373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000539858,"about_ca_topic_score_gemma":0.0007744769,"domain_scores_codex":[0.9988276,0.00007217698,0.0003832627,0.0003641771,0.0001145158,0.0002383115],"domain_scores_gemma":[0.9990833,0.0003484425,0.00007691794,0.0002827967,0.0001025335,0.0001060215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001587939,0.0005501807,0.01422263,0.00006461897,0.00009859665,0.0000833911,0.001933584,0.0008474781,0.01147186,0.0007040012,0.0006849124,0.9677508],"study_design_scores_gemma":[0.0133975,0.001785646,0.6447515,0.0009822665,0.0002433994,0.0004962638,0.003584732,0.0007995086,0.002809552,0.01313138,0.3176637,0.0003545361],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9179176,0.00232882,0.002759028,0.07042512,0.0004850389,0.00131224,0.00006048148,0.0001111784,0.004600468],"genre_scores_gemma":[0.9837302,0.0005624221,0.00636729,0.006154662,0.0001184283,0.0006183797,0.000015614,0.00002155022,0.002411455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9673963,"threshold_uncertainty_score":0.5431616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820277331758365,"score_gpt":0.3808860407791987,"score_spread":0.3626832674616151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}