{"id":"W4413920704","doi":"10.1200/po-25-00588","title":"Reply to: Germline and Somatic <i>BRCA1/2</i> Mutations in Breast Cancer Treatment Strategies","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Germline; Somatic cell; Germline mutation; Breast cancer; Oncology; Genetics; Medicine; Biology; Mutation; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004499159,0.0009018407,0.001669095,0.001487185,0.003253495,0.003499852,0.001782242,0.02700528,0.009560036],"category_scores_gemma":[0.04154709,0.0009353457,0.001081394,0.001473245,0.00294751,0.003845013,0.002744059,0.03369861,0.005995818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003367115,"about_ca_system_score_gemma":0.007264923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005565424,"about_ca_topic_score_gemma":0.009432582,"domain_scores_codex":[0.9970282,0.0006594664,0.0005988915,0.0004036291,0.000796905,0.0005128637],"domain_scores_gemma":[0.9799558,0.01093288,0.001319279,0.000377199,0.005098966,0.002315928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005082776,0.0000111681,0.0005113622,0.0001028071,0.00001441794,0.0001636939,0.00005455681,0.00004970463,0.00006292051,0.0006846361,0.9929621,0.005331777],"study_design_scores_gemma":[0.000122267,0.00005553348,0.001607985,0.0005603083,0.00008899845,0.001112675,0.0004979651,0.0002401792,0.0002267992,0.00378117,0.9916064,0.00009968933],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001700024,0.002349999,0.00006322184,0.9412701,0.05533316,0.000008809816,0.0001021998,0.00001358043,0.0006889364],"genre_scores_gemma":[0.001787427,0.002868158,0.0001643535,0.9294978,0.06357534,0.00002831857,0.00007602337,0.00001952734,0.001983095],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02700528,"threshold_uncertainty_score":0.03198153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820277331758365,"score_gpt":0.3808860407791987,"score_spread":0.3626832674616151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}