{"id":"W4413927970","doi":"10.1084/jem.20242403","title":"Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Biotechnology and Biological Sciences Research Council; École Normale Supérieure de Lyon; Association Neurofibromatoses et Recklinghause; Rheinische Friedrich-Wilhelms-Universität Bonn; H2020 European Research Council; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Université Claude Bernard Lyon 1; Studienstiftung des Deutschen Volkes; Directorate for Biological Sciences; Queen's University; Eberhard Karls Universität Tübingen; Agence Nationale de la Recherche; Academy of Medical Sciences; Queen's University Belfast; Deutsche Forschungsgemeinschaft","keywords":"Inflammasome; Pyroptosis; Chemistry; In vivo; Pharmacology; Cell biology; Medicine; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002772514,0.0006953037,0.0003663106,0.0002688355,0.0001215379,0.0004084182,0.0004645508,0.0003410239,0.001375903],"category_scores_gemma":[0.0001623146,0.0001778804,0.0003336902,0.0001951256,0.0002075131,0.0002479697,0.0002441883,0.0006580452,0.0005605376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004128107,"about_ca_system_score_gemma":0.0002973353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003248667,"about_ca_topic_score_gemma":0.0007040587,"domain_scores_codex":[0.9998693,0.00001880613,0.00001013942,0.00002397645,0.00004533594,0.00003245636],"domain_scores_gemma":[0.9999481,0.000007520178,0.00001350445,0.000006080764,0.000008712335,0.00001612202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003195822,0.0002821818,0.0001870819,0.00009403713,0.00002925384,0.0001571765,0.00002886845,0.0005885814,0.9820278,0.0007939236,0.0003955304,0.01509597],"study_design_scores_gemma":[0.000470051,0.00239779,0.001204639,0.0000196268,0.00005866681,0.0009973191,0.00001811355,0.001981135,0.9707677,0.0002293731,0.0218385,0.00001699536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9115645,0.02986236,0.04457466,0.0009991151,0.0001676053,0.0006761947,0.001733216,0.0005413874,0.009880991],"genre_scores_gemma":[0.9590271,0.01134715,0.02076897,0.000479674,0.00005345119,0.0002628973,0.001719147,0.00004295386,0.006298582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375903,"threshold_uncertainty_score":0.004602909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0084927500202485,"score_gpt":0.2769013743772436,"score_spread":0.2684086243569951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}