{"id":"W4413928690","doi":"10.3390/cimb47090707","title":"Effect of Sperm DNA Fragmentation and Chromatin Decondensation on PLCζ Efficacy in Infertile Patients","year":2025,"lang":"en","type":"review","venue":"Current Issues in Molecular Biology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Fertility Centre","funders":"","keywords":"Chromatin; DNA fragmentation; Andrology; Sperm; DNA; Cell biology; Fragmentation (computing); Biology; Chemistry; Medicine; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002686227,0.000240625,0.0002539396,0.0007623935,0.0002557727,0.000286768,0.0001534526,0.000263596,0.001491959],"category_scores_gemma":[0.001325818,0.0001096512,0.0002007613,0.0003920287,0.0002532969,0.0001723045,0.0002010598,0.0002093826,0.0001075725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838413,"about_ca_system_score_gemma":0.0001302954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007428525,"about_ca_topic_score_gemma":0.0006896901,"domain_scores_codex":[0.9997849,0.00005324385,0.00003003227,0.00003841867,0.00005783088,0.00003561335],"domain_scores_gemma":[0.9995427,0.0001187454,0.0002243709,0.00001590217,0.00003349923,0.00006480198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001109048,0.00004422229,0.9751101,0.00008882779,0.00008825832,0.001916651,0.0003641453,0.0001197715,0.00611384,0.00008056561,0.0001176977,0.01484672],"study_design_scores_gemma":[0.00002369599,0.0007635626,0.9900517,0.00002075835,0.00007031418,0.006195561,0.0002921396,0.0002668753,0.001723582,0.00006385587,0.0005189587,0.000009096116],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.998386,0.001223507,0.00009212414,0.0000280081,0.000003536585,0.000003848472,0.00004136385,0.000003852665,0.0002177022],"genre_scores_gemma":[0.9996598,0.0001937386,0.00003387199,0.00001297593,0.000004729108,0.000001778917,0.0000395935,5.663016e-7,0.00005301406],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001491959,"threshold_uncertainty_score":0.004991114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02036171401930013,"score_gpt":0.4236043555578815,"score_spread":0.4032426415385814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}