{"id":"W4413928690","doi":"10.3390/cimb47090707","title":"Effect of Sperm DNA Fragmentation and Chromatin Decondensation on PLCζ Efficacy in Infertile Patients","year":2025,"lang":"en","type":"review","venue":"Current Issues in Molecular Biology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Fertility Centre","funders":"","keywords":"Chromatin; DNA fragmentation; Andrology; Sperm; DNA; Cell biology; Fragmentation (computing); Biology; Chemistry; Medicine; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005106807,0.0002963365,0.001418682,0.000445028,0.00001342352,0.000002887493,0.00009295217,0.0003993821,0.00002635818],"category_scores_gemma":[0.001804323,0.0002228922,0.0001399126,0.0002593707,0.0001599138,0.00001653833,0.00007518734,0.0003672857,0.00001065713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147531,"about_ca_system_score_gemma":0.00006736133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007734158,"about_ca_topic_score_gemma":0.000001864573,"domain_scores_codex":[0.9974274,0.001054156,0.0006774893,0.0005891215,0.00007361508,0.0001782199],"domain_scores_gemma":[0.9989499,0.0003640734,0.000241178,0.0003545184,0.00005797757,0.00003234681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.000564387,0.0005064891,0.02096053,0.01608331,0.00006228417,0.000004195846,0.0000852528,3.491738e-7,0.0001487844,0.00009526516,0.00002031091,0.9614688],"study_design_scores_gemma":[0.02600844,0.02056243,0.4450569,0.1526252,0.002967868,0.00002087559,0.00002928465,0.00002865837,0.02329359,0.001212749,0.325936,0.002257944],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3736829,0.6245028,0.000009764859,0.00001046343,0.0002892174,0.001396595,0.00001775794,0.00000764282,0.00008285024],"genre_scores_gemma":[0.05346989,0.9445265,0.000053152,0.00002950799,0.00004830991,0.0001785908,0.001664452,0.00001655174,0.000013043],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9592109,"threshold_uncertainty_score":0.908928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02036171401930013,"score_gpt":0.4236043555578815,"score_spread":0.4032426415385814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}