{"id":"W4413929198","doi":"10.1101/2025.08.28.672976","title":"Alanine catabolism of Paneth cells maintains intestinal stem cell function during dietary restriction","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Dietary Effects on Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Syöpäsäätiö; Jane ja Aatos Erkon Säätiö; Vetenskapsrådet; Magnus Ehrnroothin Säätiö; Cancerfonden; Helsingin Yliopisto","keywords":"Catabolism; Stem cell; Function (biology); Paneth cell; Cell biology; Biology; Cell; Biochemistry; Small intestine; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231631,0.00029268,0.0002989552,0.0002028154,0.0001038999,0.0003618575,0.0001603725,0.0002378604,0.001029529],"category_scores_gemma":[0.00009072216,0.0001302907,0.0002145041,0.0001175507,0.0002439824,0.0002288176,0.0002055263,0.0004554064,0.0002292438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001847097,"about_ca_system_score_gemma":0.0001363995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003268768,"about_ca_topic_score_gemma":0.0006124387,"domain_scores_codex":[0.9998944,0.00001337651,0.00001059738,0.00003103595,0.00002833725,0.00002225194],"domain_scores_gemma":[0.9998822,0.00001101009,0.00003534066,0.00001717521,0.00001825434,0.00003612047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009115077,0.000005880661,0.0002533879,0.00002800753,0.000002599783,0.00002464273,0.000006436789,0.00001991292,0.9990583,0.00002148256,0.0000110119,0.0004772364],"study_design_scores_gemma":[0.00001268488,0.0003077755,0.01375016,0.00001278722,0.00002473008,0.0001946538,0.00006909067,0.0004991106,0.9831891,0.00006226441,0.001871922,0.000005668576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946098,0.001336192,0.002504649,0.00007256179,0.00001653249,0.00001716233,0.0004029929,0.00008270727,0.0009574061],"genre_scores_gemma":[0.9942045,0.0007368231,0.00191564,0.00005299561,0.000008633682,0.00003931485,0.0005368012,0.00002561454,0.00247976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029529,"threshold_uncertainty_score":0.003444076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449415203801987,"score_gpt":0.2316971986595433,"score_spread":0.2172030466215234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}