{"id":"W4413938413","doi":"10.1088/1741-2552/ae01db","title":"Inhibiting JNK and PI3K-Akt signaling pathways altered spontaneous network bursts and developmental trajectories of neuronal networks","year":2025,"lang":"en","type":"article","venue":"Journal of Neural Engineering","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Sanming Project of Medicine in Shenzhen","keywords":"Betweenness centrality; PI3K/AKT/mTOR pathway; Protein kinase B; Modularity (biology); Neuroscience; Synaptogenesis; Biology; Signal transduction; Cell biology; Chemistry; Centrality; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335862,0.0002520506,0.0003986185,0.0002368237,0.0001362766,0.00009085838,0.0002069956,0.0000612324,0.000002498897],"category_scores_gemma":[0.0004981934,0.0002334091,0.00008057958,0.0004989513,0.00008295951,0.0004122519,0.0001331659,0.0004948677,1.235955e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003639047,"about_ca_system_score_gemma":0.00004319022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000164199,"about_ca_topic_score_gemma":6.015645e-7,"domain_scores_codex":[0.9983437,0.00004089807,0.0006384848,0.0002741065,0.0002820663,0.0004207667],"domain_scores_gemma":[0.998893,0.0006326705,0.0002145343,0.00007385962,0.00004159368,0.0001443194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005001054,0.0000113762,0.0002866541,0.00006727053,0.00000638929,0.000396682,0.0001116664,0.1880824,0.8084033,0.0002799468,0.000009978651,0.002294258],"study_design_scores_gemma":[0.00102452,0.0004670709,0.004814161,0.0007948282,0.00005116266,0.00860843,0.0001088363,0.2995276,0.6837999,0.00008845422,0.0002277765,0.0004872156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961281,0.0004084269,0.002140258,0.00007454144,0.001066823,0.0001021081,0.000002219255,0.00004212848,0.00003532583],"genre_scores_gemma":[0.9986727,0.0001305669,0.0007281282,0.0001666304,0.0002601576,0.000001677966,1.933264e-7,0.00002444694,0.00001547534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1246034,"threshold_uncertainty_score":0.9518147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692130388863329,"score_gpt":0.2136290841448239,"score_spread":0.1967077802561906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}