{"id":"W4413940092","doi":"10.2337/db24-0341","title":"Proinflammatory Stress Activates Neutral Sphingomyelinase 2–Based Generation of a Ceramide-Enriched β-Cell EV Subpopulation","year":2025,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; School of Medicine, Indiana University; National Cancer Institute; National Institutes of Health; University of Alberta; University of Nebraska Medical Center; Purdue University; John Templeton Foundation; Doris Duke Charitable Foundation","keywords":"Ceramide; Proinflammatory cytokine; Cell biology; Sphingomyelin; Extracellular vesicle; Biology; Lipid signaling; Cell; Immunology; Inflammation; Endocrinology; Microvesicles; Apoptosis; Biochemistry; microRNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018688,0.0003400648,0.0002652376,0.0001796037,0.0001240544,0.0004121079,0.00008215331,0.0002169013,0.0009959557],"category_scores_gemma":[0.0001554333,0.0001199812,0.0003480286,0.0001015129,0.0001500524,0.0002892438,0.0003532493,0.0004793863,0.0003076809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707873,"about_ca_system_score_gemma":0.0001162193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009750216,"about_ca_topic_score_gemma":0.0001416975,"domain_scores_codex":[0.9998497,0.00002902334,0.00001444436,0.00003939408,0.00002809004,0.00003927255],"domain_scores_gemma":[0.9999186,0.00001538584,0.00002390585,0.000008846691,0.00001271314,0.00002048668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002346837,0.00001253877,0.0007739103,0.00003842207,0.000006823002,0.00007979153,0.00002076773,0.00003755036,0.997776,0.00006871772,0.00003370181,0.0009171723],"study_design_scores_gemma":[0.00002764003,0.0004250929,0.01660116,0.00001388946,0.00002333102,0.0006494507,0.0001257858,0.0009242275,0.9788503,0.0002162341,0.002135637,0.000007244976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931309,0.001589059,0.003614506,0.0001138071,0.00004949193,0.00003841845,0.0003574895,0.00004503564,0.001061312],"genre_scores_gemma":[0.995778,0.0007840111,0.001932395,0.0001147918,0.0000270734,0.00005222253,0.0004815122,0.00001364616,0.0008163434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009959557,"threshold_uncertainty_score":0.00333184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791173963805142,"score_gpt":0.2563582143278179,"score_spread":0.2384464746897664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}