{"id":"W4413940474","doi":"10.1002/bcp.70208","title":"Plasma bictegravir/emtricitabine/tenofovir alafenamide concentrations in transgender women with HIV on oestrogen‐based gender‐affirming hormone therapy in comparison to cisgender women living with HIV","year":2025,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wellesley Institute; St. Michael's Hospital; Ontario Ministry of Labour; Toronto East General Hospital; University of Toronto; Toronto General Hospital; Maple Leaf Foods; Maple Leaf Medical Clinic; Women's College Hospital","funders":"","keywords":"Tenofovir alafenamide; Emtricitabine; Human immunodeficiency virus (HIV); Transgender women; Medicine; Sex hormone-binding globulin; Tenofovir; Transgender Person; Gynecology; Internal medicine; Hormone; Pharmacology; Oncology; Virology; Antiretroviral therapy; Men who have sex with men; Viral load; Androgen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276099,0.0001793004,0.0002214139,0.0002352991,0.0002204207,0.0003843388,0.00009802393,0.0002228553,0.001902673],"category_scores_gemma":[0.0004986395,0.0001272324,0.0001301658,0.0001487192,0.0001492633,0.0001428429,0.0001549047,0.0002786442,0.000192253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618878,"about_ca_system_score_gemma":0.000131591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001688148,"about_ca_topic_score_gemma":0.001509864,"domain_scores_codex":[0.9999365,0.00001571667,0.000005793335,0.0000177441,0.000008550816,0.00001562292],"domain_scores_gemma":[0.9998529,0.00002719926,0.00004850323,0.00000779958,0.00001564243,0.00004790077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02562038,0.001424124,0.885747,0.0001689124,0.0001952703,0.001871823,0.002032059,0.0001869015,0.05181999,0.0001230387,0.0004416684,0.03036885],"study_design_scores_gemma":[0.0002112718,0.007755875,0.9836836,0.00002186281,0.0001250947,0.002570975,0.001761815,0.0004038821,0.002634111,0.00005376761,0.0007653107,0.00001256828],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995835,0.0001107059,0.00002286973,0.000008195836,0.000003858071,0.000006015619,0.00004512652,0.00000112774,0.0002185126],"genre_scores_gemma":[0.9995267,0.00006305011,0.0000489574,0.00002901479,0.000004239426,0.00001174715,0.00005755969,8.521556e-7,0.0002578771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001902673,"threshold_uncertainty_score":0.006365061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05552688845836623,"score_gpt":0.4029113948487679,"score_spread":0.3473845063904017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}