{"id":"W4413942397","doi":"10.1021/acschembio.6c00137","title":"Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Sensor Technology and Measurement Systems","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Structural Genomics Consortium; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum","keywords":"Gene isoform; Computational biology; Biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337796,0.00009135041,0.0001791043,0.00008357934,0.00003964941,0.00001078381,0.0003744268,0.000173815,7.277399e-7],"category_scores_gemma":[0.00003491556,0.00007132514,0.00002210814,0.0001549137,0.0001386587,0.00006606495,0.0001211474,0.0001008998,0.00000574956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002588403,"about_ca_system_score_gemma":0.00004271604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002118565,"about_ca_topic_score_gemma":7.816972e-7,"domain_scores_codex":[0.9992212,0.00002089972,0.0002444903,0.0002749684,0.00005264139,0.0001857925],"domain_scores_gemma":[0.9995623,0.00006367113,0.00005607982,0.0002634645,0.00003277744,0.00002176599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008226252,0.00004398261,0.003470188,0.0000164116,0.00003300626,6.185867e-7,0.0001072789,4.323713e-8,0.8903596,0.05840503,0.0002802691,0.04727536],"study_design_scores_gemma":[0.0002660077,0.00001880184,0.001774856,0.00002254339,0.000002302585,0.000005081125,0.0000327451,0.000008094976,0.9836379,0.002524775,0.01162663,0.00008032045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8980656,0.001237424,0.09842611,0.001084078,0.0002488269,0.0001204755,9.42514e-7,0.00008211932,0.000734421],"genre_scores_gemma":[0.9896193,0.0000429229,0.01006313,0.0001723623,0.00001000532,0.00001296354,0.000003180412,0.000001893517,0.00007423684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09327826,"threshold_uncertainty_score":0.2908555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02717688491058571,"score_gpt":0.2436342119516816,"score_spread":0.2164573270410959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}