{"id":"W4413943286","doi":"10.1039/d5sc90158h","title":"A focus on unexpected surprises in RiPP natural product biosynthesis","year":2025,"lang":"en","type":"article","venue":"Chemical Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biosynthesis; Natural product; Focus (optics); Enzyme; Peptide; Chemistry; Natural (archaeology); Product (mathematics); Biochemistry; Peptide Biosynthesis; Computational biology; Biology; Gene; Physics; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001565465,0.0005635332,0.0004604136,0.0005666431,0.000731859,0.001996142,0.0006624792,0.001716204,0.004756929],"category_scores_gemma":[0.001715661,0.0003912663,0.0006368157,0.0005585364,0.0009386619,0.001993652,0.00158911,0.004069351,0.002696712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007472987,"about_ca_system_score_gemma":0.0007062326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004925315,"about_ca_topic_score_gemma":0.0009771758,"domain_scores_codex":[0.9995469,0.00006203687,0.00003110089,0.0001055653,0.0001575349,0.00009684567],"domain_scores_gemma":[0.9993401,0.0001942682,0.00006198914,0.00008682871,0.0001260147,0.0001907207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001029758,0.0003532208,0.002972431,0.001156619,0.000119122,0.003389693,0.0007300677,0.00181585,0.7613657,0.01946679,0.02913835,0.1784624],"study_design_scores_gemma":[0.00007955859,0.0006356744,0.00208363,0.00008202317,0.00007100328,0.002070491,0.0003957915,0.003099014,0.7428645,0.01147629,0.2370258,0.000116083],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6257885,0.06440389,0.1532827,0.04932312,0.009527716,0.0003958826,0.004722698,0.003423164,0.08913229],"genre_scores_gemma":[0.8733554,0.02257485,0.05675683,0.006818965,0.0007571163,0.000149121,0.002799405,0.0004549366,0.03633329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004756929,"threshold_uncertainty_score":0.01591349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009218213368369107,"score_gpt":0.2659602942885114,"score_spread":0.2567420809201423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}