{"id":"W4413949664","doi":"10.1091/mbc.e25-03-0106","title":"Inside–out integrin activation is essential for early mammalian development","year":2025,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Integrin; Cell biology; Biology; Extracellular matrix; Morphogenesis; Focal adhesion; Cell adhesion; Collagen receptor; Cell growth; CD49c; Intracellular; Embryonic stem cell; Signal transduction; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001637508,0.000561174,0.0002925737,0.0002989752,0.0002484839,0.000516356,0.000306279,0.0004613078,0.002158788],"category_scores_gemma":[0.0002134768,0.0002386252,0.0002724625,0.0001628649,0.0003477199,0.0002445061,0.0004198888,0.0006729615,0.001513146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002500442,"about_ca_system_score_gemma":0.0002753881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003191083,"about_ca_topic_score_gemma":0.0004874868,"domain_scores_codex":[0.9997018,0.00003845976,0.00003486978,0.00006368893,0.0001156572,0.00004550297],"domain_scores_gemma":[0.9995517,0.00006541006,0.0001748217,0.00006497509,0.00003936593,0.0001037432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002949844,0.00001023731,0.0001943289,0.0000195358,0.000002491573,0.00008710458,0.000008544676,0.00002152963,0.9981784,0.0001776923,0.00005514219,0.001215547],"study_design_scores_gemma":[0.00001290799,0.000136246,0.01762423,0.0000146574,0.00002207878,0.0009314603,0.00003438426,0.0004732543,0.9663559,0.0002194815,0.01416505,0.00001032469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672737,0.005666314,0.01629053,0.0003852689,0.000119611,0.00006915944,0.00225544,0.000799435,0.007140541],"genre_scores_gemma":[0.9859087,0.001593638,0.00474237,0.0001368282,0.00002563717,0.00004593846,0.001510983,0.0001779463,0.005857878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002158788,"threshold_uncertainty_score":0.007221878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570378781451331,"score_gpt":0.3180505122142456,"score_spread":0.3023467243997323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}