{"id":"W4413956437","doi":"10.2147/nss.s527778","title":"The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study","year":2025,"lang":"en","type":"article","venue":"Nature and Science of Sleep","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Beijing Friendship Hospital, Capital Medical University","keywords":"Mendelian randomization; Medicine; Obstructive sleep apnea; Mendelian inheritance; Gut flora; Randomization; Sample (material); Bioinformatics; Physiology; Internal medicine; Genetics; Randomized controlled trial; Gene; Immunology; Biology; Genotype; Genetic variants","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05791494,0.002358363,0.003145664,0.001275847,0.001123499,0.00132106,0.002764071,0.003073024,0.003985645],"category_scores_gemma":[0.0859018,0.001013948,0.00699549,0.001315544,0.001653341,0.001088466,0.00135613,0.001517923,0.0003396541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008061428,"about_ca_system_score_gemma":0.002095663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002904294,"about_ca_topic_score_gemma":0.001630565,"domain_scores_codex":[0.9216921,0.06410371,0.002589335,0.007203415,0.002926266,0.001485181],"domain_scores_gemma":[0.949948,0.03370536,0.004350066,0.009886316,0.001432307,0.0006779234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.191775,0.005025734,0.579661,0.004393368,0.07164649,0.004691386,0.00237016,0.01184653,0.01568663,0.01900142,0.005658024,0.08824419],"study_design_scores_gemma":[0.05170385,0.06779823,0.506741,0.0007116299,0.07992215,0.005866612,0.0008255575,0.229357,0.01206681,0.03030539,0.01395008,0.0007516571],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7886557,0.00314858,0.1958689,0.0008767253,0.0006164486,0.006806733,0.002303324,0.0004829687,0.001240646],"genre_scores_gemma":[0.9205691,0.0003009473,0.07000738,0.000522843,0.0001006526,0.00647808,0.0009595403,0.00008247182,0.000979088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05791494,"threshold_uncertainty_score":0.3062872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002248317475830293,"score_gpt":0.2599381558173756,"score_spread":0.2576898383415453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}