{"id":"W4413960438","doi":"10.1101/2025.09.02.673847","title":"SH2-mediated steric occlusion of the C2 domain regulates autoinhibition of SHIP1 inositol 5-phosphatase","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"National Institute of General Medical Sciences","keywords":"Steric effects; Phosphatase; Chemistry; Inositol; Cell biology; Domain (mathematical analysis); Biochemistry; Biophysics; Phosphorylation; Stereochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004821543,0.0003697245,0.0004277198,0.0001482669,0.00011768,0.00002857798,0.0004815186,0.0006042556,0.00001993164],"category_scores_gemma":[0.0002101768,0.000328929,0.0002492762,0.0004265798,0.0002043691,0.000008043895,0.0009542649,0.0002795374,0.000002110703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006295107,"about_ca_system_score_gemma":0.0005993619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003281559,"about_ca_topic_score_gemma":0.000002631659,"domain_scores_codex":[0.9978722,0.000234401,0.000665068,0.0006215164,0.0003326682,0.0002741973],"domain_scores_gemma":[0.9974791,0.00002559589,0.0007430578,0.001220767,0.000434946,0.00009650409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009149325,0.00010594,0.001499237,0.0005460238,0.00008967688,0.000005514467,0.000006780631,0.0001869912,0.9968743,0.0003616803,0.0002297214,0.000002602744],"study_design_scores_gemma":[0.0005445236,0.00005310988,0.01595164,0.00088789,0.00007149643,2.873285e-8,0.000002752966,0.0001944065,0.9806026,0.00001196326,0.001371239,0.0003083461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923705,0.003645557,0.001433475,0.000182046,0.0004736433,0.0008567991,0.0009809291,0.00004810066,0.000008937136],"genre_scores_gemma":[0.9970608,0.0001457203,0.002427532,0.0001210649,0.0001313978,0.00005271701,0.00001230028,0.00003837431,0.00001008319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01627173,"threshold_uncertainty_score":0.9999163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006806663295957154,"score_gpt":0.2113403001119866,"score_spread":0.2045336368160294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}