{"id":"W4413960563","doi":"10.1093/genetics/iyaf182","title":"CDH-3/cadherin, YAP-1/YAP, and EGL-44/TEAD promote SYX-2/syntaxin and EFF-1 fusogen-mediated phagosome closure","year":2025,"lang":"en","type":"article","venue":"Genetics","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster Institute for Research on Aging, McMaster University","keywords":"Cell biology; Biology; Phagosome; Programmed cell death; Cell; Protocadherin; Cadherin; Cell adhesion; Cell fate determination; Cell growth; Cell membrane; Intracellular; Transcription factor; Genetics; Apoptosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000246844,0.0003227019,0.0002872994,0.0000901873,0.0001656461,0.0000691649,0.0002076912,0.0003918028,0.00001973818],"category_scores_gemma":[0.00009355485,0.0003199015,0.00007690083,0.0001878829,0.0001854252,0.00000359411,0.0002366984,0.0001946692,0.00001618502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001331937,"about_ca_system_score_gemma":0.0001329069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001591305,"about_ca_topic_score_gemma":0.00005503245,"domain_scores_codex":[0.9983348,0.00009709863,0.0003253685,0.0006385991,0.0001651308,0.0004389784],"domain_scores_gemma":[0.9991339,0.0000279459,0.00008828181,0.0004608686,0.00009943163,0.0001895079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005542334,0.00005961566,0.006837718,0.0001119633,0.000124261,0.00001401466,0.0001325289,0.00001805795,0.9838983,0.0000415183,0.0007245963,0.007982042],"study_design_scores_gemma":[0.001643945,0.0006311719,0.005092446,0.00009545016,0.0001288207,0.00005415789,0.0001179505,0.0003254972,0.8224965,0.0003544987,0.1684583,0.0006012904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842325,0.01356041,0.0004609573,0.0003533201,0.000239994,0.0003394741,0.0001087134,0.00004698311,0.0006575792],"genre_scores_gemma":[0.9931242,0.002249312,0.001649026,0.0006094904,0.0002402431,0.00003188401,0.0001752463,0.00004463228,0.001875984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1677337,"threshold_uncertainty_score":0.9999253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005244731295893941,"score_gpt":0.2322559324673184,"score_spread":0.2270112011714245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}