{"id":"W4413960563","doi":"10.1093/genetics/iyaf182","title":"CDH-3/cadherin, YAP-1/YAP, and EGL-44/TEAD promote SYX-2/syntaxin and EFF-1 fusogen-mediated phagosome closure","year":2025,"lang":"en","type":"article","venue":"Genetics","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster Institute for Research on Aging, McMaster University","keywords":"Cell biology; Biology; Phagosome; Programmed cell death; Cell; Protocadherin; Cadherin; Cell adhesion; Cell fate determination; Cell growth; Cell membrane; Intracellular; Transcription factor; Genetics; Apoptosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008753229,0.0002455029,0.0001503703,0.0001588637,0.000188386,0.000208157,0.0001455767,0.0002096955,0.001515954],"category_scores_gemma":[0.00007416579,0.000132397,0.0002759844,0.00005581079,0.0002696881,0.0002255384,0.000350252,0.0004943761,0.000294306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004017216,"about_ca_system_score_gemma":0.0002928226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008288062,"about_ca_topic_score_gemma":0.002446519,"domain_scores_codex":[0.9998833,0.000009132191,0.000008053536,0.000019764,0.00003247861,0.0000472519],"domain_scores_gemma":[0.9999323,0.00001094354,0.00001864761,0.00000653975,0.000005315379,0.00002626231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006063317,0.0000213811,0.0002100269,0.00002155938,0.000003711126,0.00004808863,0.00001283645,0.00006509867,0.9982241,0.0002163014,0.00006776774,0.001048486],"study_design_scores_gemma":[0.00001208565,0.00009279171,0.00751752,0.000003713329,0.000006536434,0.0001597252,0.00004438007,0.001197202,0.9888346,0.00006601546,0.002062409,0.000003054994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957926,0.0005753229,0.00198132,0.00009277319,0.0000159285,0.00001306094,0.0001316678,0.00005730179,0.001339988],"genre_scores_gemma":[0.9953485,0.000294263,0.001276014,0.00004904107,0.000004188902,0.00002058168,0.0001730774,0.0000133065,0.002821021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515954,"threshold_uncertainty_score":0.005071402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005244731295893941,"score_gpt":0.2322559324673184,"score_spread":0.2270112011714245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}