{"id":"W4413964886","doi":"10.1200/jco-24-02644","title":"Randomized Phase II Trial of Pazopanib Versus Placebo in Patients With Advanced Extrapancreatic Neuroendocrine Tumors (Alliance A021202)","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Cancer Institute","keywords":"Pazopanib; Medicine; Placebo; Internal medicine; Clinical endpoint; Neuroendocrine tumors; Hazard ratio; Adverse effect; Gastroenterology; Oncology; Randomized controlled trial; Cancer; Pathology; Confidence interval; Sunitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002397431,0.002523057,0.00339874,0.0004849991,0.0004901972,0.0012165,0.0009508092,0.002017954,0.00832005],"category_scores_gemma":[0.002900956,0.001034695,0.001588672,0.0004272552,0.001410494,0.001355609,0.0004941198,0.002879668,0.00151479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007434541,"about_ca_system_score_gemma":0.001269334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005787828,"about_ca_topic_score_gemma":0.00129784,"domain_scores_codex":[0.9989498,0.0006077886,0.00006116965,0.0002051691,0.00006260001,0.0001133521],"domain_scores_gemma":[0.9986719,0.0003937052,0.0003621649,0.00009488855,0.00008290704,0.0003944859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9863191,0.004009287,0.0003237845,0.0002790353,0.0004215658,0.00002887319,0.00002068561,0.0002293278,0.001505291,0.00008988401,0.0006463951,0.006126916],"study_design_scores_gemma":[0.9718025,0.02703976,0.0003621754,0.000008467964,0.0001056178,0.00001593003,0.000005006707,0.0002023852,0.00009810144,0.00009703437,0.0002585533,0.000004453062],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602866,0.008626257,0.002112215,0.001966054,0.002708125,0.01673618,0.00276365,0.0004038587,0.004397124],"genre_scores_gemma":[0.9670409,0.003173673,0.002793226,0.002426634,0.001484812,0.01652394,0.001649644,0.00004095926,0.004866156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00832005,"threshold_uncertainty_score":0.0278334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06837118256339604,"score_gpt":0.476552029058464,"score_spread":0.408180846495068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}