{"id":"W4413964893","doi":"10.1200/jco-25-00272","title":"Xevinapant or Placebo Plus Platinum-Based Chemoradiotherapy in Unresected Locally Advanced Squamous Cell Carcinoma of the Head and Neck (TrilynX): A Randomized, Phase III Study","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Chemoradiotherapy; Hazard ratio; Internal medicine; Adverse effect; Phases of clinical research; Head and neck squamous-cell carcinoma; Surgery; Urology; Head and neck cancer; Gastroenterology; Radiation therapy; Randomized controlled trial; Chemotherapy; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00169304,0.0009890128,0.002215891,0.0004239128,0.000416105,0.0008104734,0.00100654,0.001152004,0.004151366],"category_scores_gemma":[0.0007931722,0.0005957942,0.0008471414,0.0004257782,0.001069223,0.0007939867,0.0002709135,0.001753089,0.0006348639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006150426,"about_ca_system_score_gemma":0.001313235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009353511,"about_ca_topic_score_gemma":0.00315583,"domain_scores_codex":[0.9996159,0.0002237849,0.00002515411,0.00005428538,0.00003245002,0.0000483961],"domain_scores_gemma":[0.9994401,0.0001424695,0.0001190611,0.0000464291,0.00003469263,0.0002172193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9253642,0.02496347,0.0009060265,0.0008855104,0.000518623,0.00007701753,0.00008374889,0.0005012925,0.01147073,0.0001449294,0.0009311843,0.0341533],"study_design_scores_gemma":[0.8099609,0.1862459,0.001633738,0.00002987373,0.0002277118,0.00004850178,0.00002028162,0.0003024082,0.0008802041,0.00005377645,0.0005849647,0.00001178845],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912001,0.003469945,0.0003596562,0.0002283053,0.0002824827,0.002804813,0.0003546138,0.00009024479,0.001209752],"genre_scores_gemma":[0.9840894,0.004867007,0.001401085,0.0006615869,0.0003871543,0.004258409,0.000658831,0.00002325437,0.003653365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004151366,"threshold_uncertainty_score":0.0138877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06312164681586484,"score_gpt":0.451714309524306,"score_spread":0.3885926627084412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}