{"id":"W4413965920","doi":"10.14336/ad.2025.0699","title":"Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD","year":2025,"lang":"en","type":"article","venue":"Aging and Disease","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Leids Universitair Medisch Centrum; Argenx","keywords":"Cell; RNA; Medicine; Biomechanics; Animal model; Pharmacology; Computational biology; Chemistry; Biology; Internal medicine; Physiology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678719,0.0004044423,0.0002629127,0.0004815414,0.0002030121,0.000227357,0.0002145679,0.0003371586,0.0007217966],"category_scores_gemma":[0.0001236741,0.0001468956,0.0002077016,0.0002107657,0.0003863616,0.0001509683,0.0002547124,0.0004341849,0.000176639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004129042,"about_ca_system_score_gemma":0.0001411539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00130142,"about_ca_topic_score_gemma":0.001917259,"domain_scores_codex":[0.9998335,0.00003591332,0.00001592945,0.00003666519,0.00004990352,0.00002800338],"domain_scores_gemma":[0.9998628,0.00003349433,0.0000429956,0.00001816315,0.00001031723,0.00003218133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007101619,0.00002759439,0.0001314324,0.00001296292,0.000004332177,0.00008034322,0.000020297,0.0001275883,0.9991204,0.00006660198,0.00002065371,0.0003168872],"study_design_scores_gemma":[0.00002379587,0.000435017,0.009124051,0.00001392977,0.00002151088,0.0003744139,0.0001085521,0.004864128,0.983609,0.0001508083,0.001265482,0.000009302595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958777,0.0004755173,0.002817341,0.000064226,0.00001808119,0.00001430195,0.0002393495,0.00005761757,0.0004358023],"genre_scores_gemma":[0.9928624,0.000664829,0.002979428,0.00006348006,0.000006819642,0.0000504222,0.000508128,0.0000389562,0.002825506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130142,"threshold_uncertainty_score":0.002995908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005303800931662057,"score_gpt":0.2288668503508521,"score_spread":0.2235630494191901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}