{"id":"W4413969484","doi":"10.1016/j.cjca.2025.08.340","title":"Gene Replacement Therapy in Patients With Cardiac Disease: Challenges in Trial Design and Management of Adverse Events","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Sarnoff Cardiovascular Research Foundation; Bristol-Myers Squibb","keywords":"Medicine; Adverse effect; Intensive care medicine; Genetic enhancement; Internal medicine; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4006519,0.001150083,0.007771747,0.001460914,0.001245108,0.007221553,0.004302055,0.004569318,0.004227523],"category_scores_gemma":[0.3772845,0.0006976507,0.004110806,0.002188375,0.005591306,0.005145754,0.003157762,0.009780956,0.001488174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003919374,"about_ca_system_score_gemma":0.01224732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001688005,"about_ca_topic_score_gemma":0.002902181,"domain_scores_codex":[0.5714258,0.3927134,0.01708065,0.004522294,0.01302263,0.001235276],"domain_scores_gemma":[0.4316637,0.4749701,0.02463791,0.03046744,0.0297989,0.008461952],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.02102924,0.00110225,0.009578196,0.01285803,0.006550683,0.0002380922,0.001162568,0.005521744,0.001692594,0.04498459,0.05757015,0.8377118],"study_design_scores_gemma":[0.04694599,0.04242592,0.04058631,0.048051,0.009678293,0.001364265,0.001867242,0.02863713,0.003828943,0.3874538,0.388287,0.0008741303],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.03296707,0.2928092,0.2013061,0.4054428,0.02720366,0.01930108,0.002903134,0.00119118,0.01687577],"genre_scores_gemma":[0.3235648,0.07462528,0.362429,0.1354079,0.02645373,0.07258023,0.001460901,0.0009092347,0.002569058],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5993481,"threshold_uncertainty_score":0.7391028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112217922836198,"score_gpt":0.251036728465834,"score_spread":0.239914549237472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}