{"id":"W4413977058","doi":"10.1113/jp287774","title":"KCC2 enhancers normalize reflex responses and improve locomotor function after chronic spinal cord injury","year":2025,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Université Laval","keywords":"Reflex; Spasticity; Medicine; Spinal cord injury; Reciprocal inhibition; Hyperreflexia; Spinal cord; Spastic; Neuroscience; Stretch reflex; Anesthesia; Physical medicine and rehabilitation; Stimulation; Internal medicine; Psychology; Cerebral palsy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756035,0.0006518305,0.0006535486,0.0005351058,0.0002057128,0.0003598153,0.0004042074,0.000438305,0.001581307],"category_scores_gemma":[0.0001555775,0.0001872226,0.0003046121,0.0002029539,0.0004537816,0.0003097677,0.000237338,0.001044911,0.000306894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003235938,"about_ca_system_score_gemma":0.0004511934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001593937,"about_ca_topic_score_gemma":0.003888115,"domain_scores_codex":[0.9997783,0.0000193216,0.00003151292,0.00004085308,0.00005686213,0.00007314757],"domain_scores_gemma":[0.9997982,0.00001625075,0.00005774441,0.00002127236,0.00002997798,0.00007650855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006910399,0.00040802,0.0001598602,0.00009900866,0.00001778293,0.00006360244,0.00002647844,0.0001102564,0.9952348,0.00006486276,0.00009314121,0.003031097],"study_design_scores_gemma":[0.0002026371,0.00523817,0.007340399,0.00003218371,0.00008066561,0.0003343439,0.0001065229,0.0008063727,0.9836137,0.00007340695,0.002154246,0.00001734936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970397,0.0007169435,0.0008644451,0.0000841952,0.00004766979,0.00004308558,0.0003075037,0.0001853861,0.000710966],"genre_scores_gemma":[0.9925209,0.001133719,0.001444603,0.0001013718,0.00002051251,0.00009156723,0.0006250649,0.00006314299,0.003999273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593937,"threshold_uncertainty_score":0.005290031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091367347631012,"score_gpt":0.3255113562779661,"score_spread":0.314597682801656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}