{"id":"W4413981169","doi":"10.1136/heartjnl-2025-326218","title":"Benefit–risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial","year":2025,"lang":"en","type":"article","venue":"Heart","topic":"Advanced Causal Inference Techniques","field":"Mathematics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Southlake Regional Health Center; Genome Prairie; Health Sciences Centre; Centre Hospitalier Universitaire de Sherbrooke; Sunnybrook Health Science Centre; University of Ottawa; Hamilton Health Sciences; Population Health Research Institute","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; Boston Scientific Corporation; Population Health Research Institute","keywords":"Medicine; Spironolactone; Myocardial infarction; Internal medicine; Placebo; Stroke (engine); Relative risk; Cardiology; Heart failure; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1008318,0.00295504,0.006778529,0.001506411,0.0003671502,0.001394023,0.001914751,0.001893018,0.007886244],"category_scores_gemma":[0.1411917,0.0007343625,0.0170767,0.001182111,0.001957167,0.00269319,0.002793279,0.00404571,0.0004282693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008326585,"about_ca_system_score_gemma":0.001032541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004190954,"about_ca_topic_score_gemma":0.0006295741,"domain_scores_codex":[0.820381,0.1595155,0.005056235,0.006856847,0.00668694,0.001503537],"domain_scores_gemma":[0.8519601,0.122725,0.01046348,0.0118728,0.001794437,0.001184183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6750724,0.0008626705,0.02076141,0.01340009,0.1791317,0.0008129684,0.0008570888,0.01425573,0.005563324,0.007308007,0.005357843,0.07661693],"study_design_scores_gemma":[0.2272469,0.2308991,0.1583604,0.002595273,0.1903743,0.001325167,0.0008704279,0.1177704,0.007719482,0.04650315,0.01554537,0.0007899925],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8136353,0.01921141,0.1336865,0.001980595,0.001266898,0.01557516,0.006112448,0.0008233269,0.00770833],"genre_scores_gemma":[0.9520388,0.0007793345,0.03532572,0.0005852457,0.000204208,0.00816452,0.001318796,0.0001948894,0.001388525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1008318,"threshold_uncertainty_score":0.5332557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08060094350871745,"score_gpt":0.3891539290421738,"score_spread":0.3085529855334563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}