{"id":"W4413984080","doi":"10.1101/2025.08.31.673358","title":"Dysregulation of an H3K79me2-dependent epigenetic barrier impairs neural progenitor cell proliferation and differentiation in Fragile X syndrome","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Fragile X syndrome; Fragile x; Epigenetics; Progenitor cell; Progenitor; Neural stem cell; FMR1; Neuroscience; Biology; Cell biology; Genetics; Stem cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050293,0.0002393776,0.0001977308,0.0002080145,0.0001099872,0.0001454954,0.0001375708,0.0002003559,0.001661788],"category_scores_gemma":[0.00007398404,0.0001067017,0.0002087366,0.00007371299,0.0002179883,0.0000993493,0.0002495119,0.0003434106,0.0001928267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001618937,"about_ca_system_score_gemma":0.000123923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009319498,"about_ca_topic_score_gemma":0.001278085,"domain_scores_codex":[0.9999248,0.000008721543,0.000009675998,0.0000196684,0.00002437643,0.00001290751],"domain_scores_gemma":[0.9999567,0.000005016283,0.00001492716,0.000004497665,0.000004111313,0.00001484838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001194157,0.0000168329,0.0009013806,0.00003300729,0.00001174015,0.0001017471,0.00001662881,0.0000780909,0.9969405,0.00007535936,0.00004107346,0.001664208],"study_design_scores_gemma":[0.0000249235,0.0005858661,0.0675147,0.00002154628,0.00004910854,0.001179546,0.00009832304,0.001632598,0.9262424,0.0001437523,0.002498041,0.000009164509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971638,0.0008110962,0.001136817,0.00003589259,0.00001432989,0.000006859418,0.0002834617,0.00004270316,0.0005049655],"genre_scores_gemma":[0.9979764,0.0003412143,0.0004489666,0.00002428091,0.000002637967,0.00001276153,0.000224379,0.000009117314,0.0009603481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001661788,"threshold_uncertainty_score":0.005559206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005638646112077778,"score_gpt":0.2017294997046353,"score_spread":0.1960908535925575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}