{"id":"W4413984867","doi":"10.1158/1078-0432.ccr-25-1796","title":"Prognosis and Biological Characteristics of ER-Low Metastatic Breast Cancer: Results from a Multicenter Cohort and the TONIC Trial","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; Università degli Studi di Padova; Ministero della Salute; Gilead Sciences","keywords":"Medicine; Breast cancer; Internal medicine; Retrospective cohort study; Cohort; Metastatic breast cancer; Oncology; Metastasis; Prospective cohort study; Cohort study; Gastroenterology; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003844791,0.000560155,0.00103743,0.0002997821,0.0003037337,0.0007429449,0.000525654,0.0004877025,0.001454034],"category_scores_gemma":[0.003348281,0.0002623474,0.001017508,0.0006225295,0.0003370269,0.0006930977,0.0005866194,0.0005911734,0.0002687866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004546671,"about_ca_system_score_gemma":0.0004935382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000931549,"about_ca_topic_score_gemma":0.001721825,"domain_scores_codex":[0.9985254,0.000796511,0.0001188592,0.0002980886,0.0001616737,0.00009946778],"domain_scores_gemma":[0.9967327,0.0004916121,0.001269435,0.0006769989,0.0003074307,0.0005218838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2270767,0.001027242,0.7443875,0.0003494479,0.003675165,0.000218404,0.0002553233,0.0006505048,0.004516258,0.000192471,0.003017431,0.01463356],"study_design_scores_gemma":[0.02605929,0.02214368,0.9416423,0.0001155298,0.003405192,0.000976019,0.0003790013,0.001125195,0.0008928634,0.0001658988,0.003024503,0.00007051955],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976313,0.0006668266,0.00009274447,0.00006755242,0.00001610956,0.00005023322,0.001122768,0.000004427913,0.0003480181],"genre_scores_gemma":[0.9948047,0.0003182512,0.000139796,0.0001106588,0.00006020218,0.00008430421,0.004236217,0.000007305958,0.0002386291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003844791,"threshold_uncertainty_score":0.02033347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1012601298136648,"score_gpt":0.463870641970623,"score_spread":0.3626105121569582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}