{"id":"W4413985376","doi":"10.1111/all.70025","title":"HLA‐A*02:01 Presents Penicillin‐Modified Cysteinylated Peptides for T Cell Recognition","year":2025,"lang":"en","type":"article","venue":"Allergy","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Health and Medical Research Council; Medical Research Council; Leibniz-Gemeinschaft; Australian Research Data Commons; Faculty of Medicine, Nursing and Health Sciences, Monash University; Monash University","keywords":"T-cell receptor; Peptide; CD8; Chemistry; Epitope; Human leukocyte antigen; T cell; Context (archaeology); Cysteine; Antigen; Major histocompatibility complex; Cytotoxic T cell; Immune system; Biochemistry; Biology; Immunology; In vitro; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009655959,0.0002354313,0.0001249211,0.00009993013,0.0001209103,0.0002830337,0.0001319545,0.0003560482,0.005211575],"category_scores_gemma":[0.0002762566,0.00008837309,0.0001383923,0.00009418971,0.0001054371,0.0001711464,0.0001599851,0.0003738067,0.0009017873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150822,"about_ca_system_score_gemma":0.0000687672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001040216,"about_ca_topic_score_gemma":0.00008226212,"domain_scores_codex":[0.999868,0.00003105527,0.00001000967,0.00002665217,0.00001870262,0.00004557282],"domain_scores_gemma":[0.9998393,0.00005711185,0.00002925039,0.00002296207,0.00001549957,0.00003592936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002009442,0.00008891556,0.01171384,0.00002760651,0.00000711398,0.001686903,0.00008090999,0.00003767659,0.9825402,0.00008104197,0.0001159431,0.003418777],"study_design_scores_gemma":[0.0001203924,0.004440019,0.1239856,0.00004075611,0.00009695203,0.06842622,0.0006031349,0.002029386,0.7889508,0.0003229368,0.0109694,0.0000143445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998218,0.00009574733,0.0004446791,0.0000340673,0.000005309638,0.000009917079,0.00002195499,0.00001352901,0.001156739],"genre_scores_gemma":[0.9989729,0.0000580745,0.0003339122,0.00005705279,0.00001023799,0.000008604323,0.00005347513,0.000004599549,0.0005011755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005211575,"threshold_uncertainty_score":0.01743442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03567302437730056,"score_gpt":0.3006440317922895,"score_spread":0.264971007414989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}