{"id":"W4413988242","doi":"10.1016/j.ebiom.2025.105914","title":"A strategy to re-sensitise drug-resistant Gram-positive bacteria to oxazolidinone-class antibiotics","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Innovation and Technology Fund; Hong Kong Polytechnic University; Hong Kong University of Science and Technology; Research Grants Council, University Grants Committee; National Natural Science Foundation of China","keywords":"Antibiotics; Medicine; Gram-negative bacterial infections; Drug resistance; Bacteria; Drug; Microbiology; Pharmacology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475236,0.0004799331,0.000275594,0.000300311,0.0001435902,0.000309986,0.0002546857,0.0004421072,0.001049989],"category_scores_gemma":[0.0001450484,0.0001490245,0.0003162035,0.0001513915,0.0002180603,0.000403886,0.0003537081,0.0005380148,0.0003324908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002091348,"about_ca_system_score_gemma":0.0002105774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001794041,"about_ca_topic_score_gemma":0.0003380774,"domain_scores_codex":[0.9998785,0.00002001185,0.000009728567,0.00003146467,0.00003270925,0.00002754976],"domain_scores_gemma":[0.9999164,0.00001040049,0.00002934703,0.00001000162,0.00001609978,0.00001778084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007324096,0.00005900008,0.0001002106,0.0001676437,0.000007269765,0.00007360361,0.00001667869,0.0001643952,0.9909589,0.000179827,0.0001412087,0.008057952],"study_design_scores_gemma":[0.00002835568,0.001058892,0.001000367,0.00002110741,0.00003261457,0.0004267043,0.00002770678,0.001078291,0.9887589,0.0001049799,0.007446871,0.00001511468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9310156,0.0188589,0.04067795,0.0009695257,0.000351621,0.0003382007,0.0003942524,0.000534367,0.006859691],"genre_scores_gemma":[0.9709161,0.006537241,0.01802638,0.0003758919,0.00004228664,0.0001305459,0.0002030467,0.00003058924,0.003738063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049989,"threshold_uncertainty_score":0.003512561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006996986058824899,"score_gpt":0.2650935490401052,"score_spread":0.2580965629812804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}