{"id":"W4413993652","doi":"10.1242/dev.204697","title":"Chd4 remodels chromatin to control retinal cell type specification and lineage termination","year":2025,"lang":"en","type":"article","venue":"Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canada Foundation for Innovation; Canadian Institutes of Health Research; University of Ottawa","keywords":"Biology; Cell biology; Chromatin; Progenitor cell; Nucleosome; Progenitor; Cellular differentiation; Neural stem cell; Neural development; Genetics; Neuroscience; Stem cell; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300688,0.0001854503,0.0001429614,0.0002861172,0.000191824,0.0003718834,0.0002751393,0.0002100631,0.0013736],"category_scores_gemma":[0.000188367,0.0002200908,0.0001901541,0.0001469285,0.0002947272,0.0002310013,0.0003413297,0.0003294971,0.0004229894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004492052,"about_ca_system_score_gemma":0.0002625776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001440402,"about_ca_topic_score_gemma":0.003952153,"domain_scores_codex":[0.9998697,0.000007968124,0.000006695144,0.00004401677,0.0000420957,0.00002954253],"domain_scores_gemma":[0.99989,0.00001827465,0.0000329153,0.0000124634,0.0000194647,0.000026929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000447577,0.000003613912,0.001544468,0.00002258408,0.00000460203,0.00003065819,0.00001696145,0.00009227413,0.9963085,0.0002184507,0.00005433494,0.001658752],"study_design_scores_gemma":[0.00001079788,0.00004973525,0.05021624,0.000009417318,0.00002146926,0.0001502068,0.00007262653,0.002814658,0.94086,0.0002660196,0.005517692,0.00001126055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97865,0.001588247,0.0152509,0.0001104219,0.00005609525,0.00002320528,0.001297044,0.0002156775,0.002808389],"genre_scores_gemma":[0.9898544,0.0004669677,0.0042306,0.00006398224,0.000008578045,0.00001787249,0.0009159034,0.00005156712,0.004390161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440402,"threshold_uncertainty_score":0.004595101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004850327787166503,"score_gpt":0.2332814756817365,"score_spread":0.2284311478945699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}