{"id":"W4413997981","doi":"10.1101/2025.09.02.673730","title":"Enzymatic Function of an Intrinsically Disordered Protein","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Function (biology); Enzyme; Intrinsically disordered proteins; Chemistry; Protein function; Biophysics; Biochemistry; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002898291,0.0003514237,0.0002016013,0.0001712919,0.0002013901,0.0005537429,0.0002325289,0.0003422745,0.0005820315],"category_scores_gemma":[0.0002498649,0.00009867414,0.0001564932,0.0001468135,0.0003095903,0.0001993756,0.0002226024,0.0003903589,0.0003588587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005142265,"about_ca_system_score_gemma":0.0001955186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002408038,"about_ca_topic_score_gemma":0.000153924,"domain_scores_codex":[0.9998739,0.00002312714,0.00001234644,0.00004013274,0.00003160231,0.00001883585],"domain_scores_gemma":[0.9998347,0.00003871457,0.00003293352,0.0000246714,0.00001747622,0.00005153396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008353969,0.00002218853,0.0008976389,0.0000489258,0.000009966248,0.0003319488,0.00001565493,0.0005463195,0.9952465,0.001253844,0.0001342118,0.001409327],"study_design_scores_gemma":[0.00001414847,0.0001057456,0.002542567,0.000006513354,0.00001340694,0.001153891,0.00002758008,0.007528396,0.982988,0.0007892584,0.004820554,0.00000991039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855795,0.002409282,0.009316694,0.0002436837,0.0000861452,0.000009974228,0.000320502,0.0001618073,0.001872477],"genre_scores_gemma":[0.9959877,0.0002660474,0.002422085,0.00003141195,0.000009260522,0.000004761888,0.0003031734,0.00001135385,0.0009642299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005820315,"threshold_uncertainty_score":0.003730953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006903723565010298,"score_gpt":0.2097439004646178,"score_spread":0.2028401768996075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}