{"id":"W4413997981","doi":"10.1101/2025.09.02.673730","title":"Enzymatic Function of an Intrinsically Disordered Protein","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Function (biology); Enzyme; Intrinsically disordered proteins; Chemistry; Protein function; Biophysics; Biochemistry; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002663453,0.0003085267,0.0003071934,0.000144964,0.00006804487,0.00005322893,0.0003049309,0.0004804365,0.00001974636],"category_scores_gemma":[0.0002085111,0.000341646,0.0001041021,0.0002263283,0.00007372953,0.00001182743,0.0002932866,0.000272228,0.000006354776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003294008,"about_ca_system_score_gemma":0.0003824895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000941776,"about_ca_topic_score_gemma":0.000002710639,"domain_scores_codex":[0.9982809,0.0001467103,0.0004504459,0.0007186381,0.0001876909,0.0002156585],"domain_scores_gemma":[0.9979955,0.000004341362,0.0003678326,0.001056505,0.0004751073,0.000100734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001045922,0.0002061354,0.0003137711,0.0003815097,0.00009505466,7.625252e-7,0.00000318311,0.00003672862,0.9983469,0.0003815468,0.0001131017,0.00001676599],"study_design_scores_gemma":[0.0003623688,0.000176734,0.01420789,0.0001470832,0.00006924332,4.399427e-9,0.000002343188,0.0001192714,0.976666,0.000005127205,0.007890414,0.0003535463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872772,0.0004145218,0.01056346,0.0001426244,0.0006421104,0.000723288,0.0001323455,0.00008995657,0.0000145572],"genre_scores_gemma":[0.9965226,0.00009768805,0.002543567,0.0001139923,0.0004318742,0.0001840567,0.000009529728,0.00004398028,0.00005271717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02168087,"threshold_uncertainty_score":0.9999036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006903723565010298,"score_gpt":0.2097439004646178,"score_spread":0.2028401768996075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}