{"id":"W4413998524","doi":"10.1101/2025.09.03.674079","title":"Aminopeptidase N is a receptor for hedgehog merbecoviruses","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hedgehog; Aminopeptidase; Receptor; Chemistry; Cell biology; Biology; Biochemistry; Signal transduction; Amino acid; Leucine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478084,0.0002348994,0.000181891,0.0001299156,0.0001511536,0.0003244974,0.0001374819,0.000283449,0.001200244],"category_scores_gemma":[0.0001651026,0.00008616368,0.0002111182,0.0001065055,0.0001452778,0.0001634288,0.0001631556,0.0001922937,0.0003077037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044907,"about_ca_system_score_gemma":0.0001201184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00126941,"about_ca_topic_score_gemma":0.001057127,"domain_scores_codex":[0.9998834,0.00002079745,0.000009010593,0.00002898415,0.00003205085,0.00002561519],"domain_scores_gemma":[0.9999399,0.00002082562,0.00001185715,0.000007557574,0.000008298931,0.00001156492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000862922,0.000008076287,0.001249861,0.00002842702,0.000005280491,0.00004473861,0.000008485279,0.00005386075,0.9977002,0.00005506308,0.00003657806,0.0007230793],"study_design_scores_gemma":[0.00001397911,0.0002294465,0.03110346,0.00001222708,0.00002593792,0.0009526482,0.0001197969,0.002915989,0.9602475,0.0001649725,0.004206263,0.000007716588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963601,0.0007659897,0.00137116,0.00004124883,0.0000108308,0.0000111806,0.0002493722,0.00001414549,0.001175817],"genre_scores_gemma":[0.994278,0.0003697027,0.002743725,0.0000426363,0.000005877138,0.0000069799,0.0008968936,0.000006767707,0.001649421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00126941,"threshold_uncertainty_score":0.004015148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119423324459644,"score_gpt":0.2411590726346242,"score_spread":0.2099648393900277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}