{"id":"W4413998524","doi":"10.1101/2025.09.03.674079","title":"Aminopeptidase N is a receptor for hedgehog merbecoviruses","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hedgehog; Aminopeptidase; Receptor; Chemistry; Cell biology; Biology; Biochemistry; Signal transduction; Amino acid; Leucine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003736365,0.0006028895,0.0006473413,0.00007242233,0.0006440483,0.0002324233,0.0006621696,0.0005408684,0.0003335366],"category_scores_gemma":[0.000384102,0.0003119704,0.0003941997,0.0006017931,0.000163124,0.0001240912,0.0008061898,0.0004653163,0.0001794008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248766,"about_ca_system_score_gemma":0.0001315204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003078204,"about_ca_topic_score_gemma":0.00006381445,"domain_scores_codex":[0.9973502,0.0000959411,0.0005194856,0.001155975,0.0002556447,0.0006227887],"domain_scores_gemma":[0.9982105,0.0003272076,0.0003312962,0.0003443865,0.0006033746,0.0001832502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007940988,0.0002424562,0.009315795,0.0003055857,0.0002981698,0.00000292138,0.00001255841,0.000003831472,0.9654959,0.0008256448,0.02336125,0.00005651412],"study_design_scores_gemma":[0.0003770601,0.0003265692,0.08586393,0.0005982128,0.0002619045,5.494891e-9,0.00001518766,0.00006062719,0.413274,0.00001715462,0.4977083,0.001497073],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868792,0.001905601,0.0001651757,0.001364416,0.00167197,0.001776514,0.005299251,0.0008055576,0.0001323074],"genre_scores_gemma":[0.99278,0.0006524827,0.002646847,0.001432697,0.001181984,0.0011245,0.000001585859,0.00001045574,0.000169437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5522219,"threshold_uncertainty_score":0.9999332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119423324459644,"score_gpt":0.2411590726346242,"score_spread":0.2099648393900277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}