{"id":"W4414000607","doi":"10.1101/2025.09.03.674067","title":"Adolescent stress impairs parvalbumin interneurons and their associated perineuronal nets: protective effects of microglia-modulating minocycline treatment","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Perineuronal net; Minocycline; Parvalbumin; Microglia; Neuroscience; Interneuron; Medicine; Psychology; Biology; Inflammation; Immunology; Microbiology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008643698,0.0004064859,0.0003697759,0.0001617878,0.0001174077,0.0001957559,0.0001832266,0.0002627358,0.0009172309],"category_scores_gemma":[0.0001152074,0.0001232387,0.0002534839,0.00007751097,0.0001902297,0.0001513092,0.0001719312,0.0007250275,0.0001124424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001677615,"about_ca_system_score_gemma":0.0002462563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008336846,"about_ca_topic_score_gemma":0.002693834,"domain_scores_codex":[0.9998796,0.00001568695,0.00001559087,0.00002230258,0.00002236593,0.000044377],"domain_scores_gemma":[0.9998006,0.00001204639,0.00008441642,0.00001299905,0.00002403325,0.00006595257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008146724,0.0001762406,0.0007223433,0.0001009112,0.00001284086,0.00005627756,0.00005479687,0.00003860361,0.9950977,0.00003290028,0.00004600176,0.002846672],"study_design_scores_gemma":[0.00008648361,0.006422037,0.05485256,0.00007126939,0.00006412272,0.0002467983,0.0003197547,0.0007317351,0.935177,0.00007203725,0.001943777,0.00001237158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972324,0.001426755,0.0006157357,0.00007019878,0.00003492205,0.00002635695,0.0001571646,0.00003904573,0.0003974262],"genre_scores_gemma":[0.9967506,0.001170079,0.0007880637,0.00005151856,0.00001965426,0.00006464883,0.0001372754,0.000009482832,0.001008629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009172309,"threshold_uncertainty_score":0.003068447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00984006416849069,"score_gpt":0.2323260440902991,"score_spread":0.2224859799218084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}