{"id":"W4414003126","doi":"10.1177/18796397251372667","title":"Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases","year":2025,"lang":"en","type":"review","venue":"Journal of Huntington s Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Neurodegeneration; Huntington's disease; PARP1; Amyotrophic lateral sclerosis; Neuroscience; Biology; Disease; Immune dysregulation; Medicine; Genetics; Immune system; Poly ADP ribose polymerase; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005532292,0.0005379404,0.001454462,0.0007773698,0.0002502078,0.0001790835,0.0005813134,0.0001089048,0.00002270866],"category_scores_gemma":[0.00405047,0.0003871205,0.0006264783,0.001066797,0.0003006035,0.0003706834,0.0002331981,0.0005064477,0.000001803523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006963671,"about_ca_system_score_gemma":0.0008927669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003873703,"about_ca_topic_score_gemma":0.00000317622,"domain_scores_codex":[0.9946945,0.001641969,0.001890265,0.0006324162,0.000779812,0.0003610195],"domain_scores_gemma":[0.9944587,0.00187405,0.00268525,0.0004415293,0.0002777551,0.0002626962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007181298,0.001833236,0.02813554,0.05425502,0.0002492612,0.00009251488,0.001133604,0.009116783,0.01824148,0.0009585328,0.000653088,0.8846128],"study_design_scores_gemma":[0.01104822,0.001787563,0.1713376,0.2990895,0.03462744,0.0001030914,0.001100248,0.00410321,0.3240774,0.007135327,0.1369687,0.008621739],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3037164,0.6945043,0.00007850336,0.0001316766,0.000439753,0.0009368298,0.0001213273,0.00001800538,0.00005325852],"genre_scores_gemma":[0.278594,0.7206777,0.00008403452,0.0001546892,0.0003300984,0.0000370738,0.00001788136,0.00005678719,0.00004780644],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8759911,"threshold_uncertainty_score":0.9998581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03165899541838427,"score_gpt":0.3118529019988592,"score_spread":0.2801939065804749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}