{"id":"W4414006216","doi":"10.1101/2025.09.03.25335032","title":"Cognitive reserve as a moderator of the association between brain structure and later-life behavioural symptoms across the neurocognitive spectrum","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Neurocognitive; Cognitive reserve; Moderation; Association (psychology); Psychology; Cognition; Cognitive psychology; Spectrum (functional analysis); Clinical psychology; Cognitive impairment; Neuroscience; Social psychology; Psychotherapist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001835125,0.0008135337,0.000553185,0.0006736132,0.0004654027,0.0008815015,0.000627554,0.0006893136,0.002734411],"category_scores_gemma":[0.005490396,0.0002697802,0.001147972,0.0005756472,0.0003913717,0.0005261249,0.0008653579,0.0008139629,0.0001413636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002781773,"about_ca_system_score_gemma":0.0004700827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009462123,"about_ca_topic_score_gemma":0.008901535,"domain_scores_codex":[0.9992746,0.0002817654,0.00006168486,0.0002163158,0.00005927589,0.0001063675],"domain_scores_gemma":[0.9971673,0.001096843,0.0008519138,0.0002827184,0.0001923704,0.0004088576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000846647,0.00008032499,0.9933676,0.00005125291,0.001107391,0.00009515133,0.000165612,0.000125256,0.0005722391,0.0000633703,0.0001518918,0.003373192],"study_design_scores_gemma":[0.00001435896,0.0001702466,0.9985889,0.00001918966,0.0003623565,0.00008491513,0.00008915066,0.0002978868,0.0001206747,0.0001297961,0.000118275,0.000004281811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977059,0.001239056,0.0002254428,0.0001860243,0.00001976295,0.00000731105,0.0002852126,0.00001113003,0.0003200881],"genre_scores_gemma":[0.9995074,0.00009169633,0.0001194197,0.00002769056,0.00001397018,0.000007354734,0.000107972,0.000002841859,0.0001216542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009462123,"threshold_uncertainty_score":0.01881409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02383962523444935,"score_gpt":0.3391794427277827,"score_spread":0.3153398174933334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}