{"id":"W4414016243","doi":"10.1002/ijc.70039","title":"Genetically determined body mass index is associated with diffuse large B‐cell lymphoma in polygenic and Mendelian randomization analyses","year":2025,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Genome British Columbia; Simon Fraser University; Canadian Centre for Applied Research in Cancer Control; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; Bundesamt für Strahlenschutz; Blood Cancer UK; Institut National Du Cancer; Instituto de Salud Carlos III; José Carreras Leukämie-Stiftung; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Generalitat de Catalunya; Fondation de France; European Regional Development Fund; World Health Organization; European Commission; Centres de Recerca de Catalunya; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Compagnia di San Paolo; Michael Smith Health Research BC; Centre International de Recherche sur le Cancer; Cancer Research UK; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Odds ratio; Body mass index; Internal medicine; Diffuse large B-cell lymphoma; Medicine; Follicular lymphoma; Waist–hip ratio; Confidence interval; Oncology; Lymphoma; Biology; Waist; Genetics; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00693105,0.0006294199,0.000617268,0.002013087,0.0004807626,0.0008030595,0.0005296021,0.000613759,0.00194589],"category_scores_gemma":[0.01206997,0.0004075691,0.001468978,0.001830619,0.000617934,0.0002788975,0.0006996808,0.0004979688,0.0001462463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423923,"about_ca_system_score_gemma":0.0003146446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003433431,"about_ca_topic_score_gemma":0.002139908,"domain_scores_codex":[0.990252,0.007314515,0.0004319582,0.001172128,0.000554365,0.0002750595],"domain_scores_gemma":[0.989689,0.005973419,0.002095593,0.001652605,0.0002819533,0.0003073869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002110928,0.00008734129,0.9819617,0.00003655846,0.002925486,0.000905929,0.0001641048,0.0009037596,0.004194088,0.0008005793,0.0001943416,0.005715304],"study_design_scores_gemma":[0.0002411411,0.0005927347,0.9791748,0.00002833232,0.002015929,0.002924497,0.0001496016,0.01211938,0.0007868009,0.001379701,0.0005484739,0.00003857544],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924446,0.0005878169,0.006147441,0.00008985239,0.00001484901,0.0000301551,0.0002265408,0.0000494758,0.0004092442],"genre_scores_gemma":[0.9984231,0.00007771077,0.001264966,0.00001769448,0.000007539104,0.00001711603,0.0001045429,0.000008898498,0.00007858504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00693105,"threshold_uncertainty_score":0.03665537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008444266780224603,"score_gpt":0.3164158357124381,"score_spread":0.3079715689322136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}