{"id":"W4414018591","doi":"10.1021/acs.jproteome.5c00473","title":"BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associated with Multiple Cellular Pathways","year":2025,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; College of Human Medicine, Michigan State University; College of Engineering, Michigan State University; National Institutes of Health; Fulbright Association; Michigan State University","keywords":"Interactome; Computational biology; Protein–protein interaction; Biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001307723,0.0001370607,0.0002330943,0.0003388372,0.0002303399,0.00006337909,0.0002004482,0.0001742039,0.00001055849],"category_scores_gemma":[0.001273704,0.00009401095,0.00008585214,0.0003942813,0.000230824,0.00001053564,0.0001526235,0.0008186331,0.000002219499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006990016,"about_ca_system_score_gemma":0.0002972053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001533452,"about_ca_topic_score_gemma":0.00002631933,"domain_scores_codex":[0.9985745,0.0002305876,0.000352243,0.0002148039,0.0003185825,0.0003093168],"domain_scores_gemma":[0.9984937,0.0001095563,0.0002007158,0.0001778015,0.000917806,0.0001003763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003901386,0.0002965057,0.002397253,0.00007274767,0.0002950246,0.00001760903,0.0000592537,0.00000935976,0.9950398,0.00002736444,0.0008228623,0.0005720975],"study_design_scores_gemma":[0.002876564,0.00174556,0.007119103,0.001465164,0.00003546939,0.00002632135,0.0003364004,0.0002125672,0.9754179,0.0001483129,0.01042226,0.0001944183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920833,0.001435003,0.003539316,0.00157407,0.00009647574,0.0006659834,0.00001968651,0.000006645329,0.0005795123],"genre_scores_gemma":[0.995903,0.00008835852,0.001481249,0.00003722226,0.00009534613,0.00003756893,0.000009816629,0.0000153962,0.00233201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01962193,"threshold_uncertainty_score":0.3833655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03867292164363653,"score_gpt":0.3298696536154588,"score_spread":0.2911967319718223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}