{"id":"W4414019364","doi":"10.1080/19490976.2025.2546998","title":"Metabolomics reveal distinct molecular pathways associated with future risk of Crohn’s Disease","year":2025,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; St. Paul's Hospital; University of Manitoba; Queen's University; BC Children's Hospital; Children's Hospital of Eastern Ontario; University of Ottawa; McGill University Health Centre; Centre Hospitalier Universitaire Sainte-Justine; University of British Columbia; University Health Network; Health Sciences Centre; Ontario College of Art and Design; Hospital for Sick Children; Université de Montréal; University of Alberta; University of Toronto; Princess Margaret Cancer Centre; University of Calgary; Mount Sinai Hospital","funders":"Temerty Faculty of Medicine, University of Toronto; Canadian Institutes of Health Research; Leonard M. Miller School of Medicine; Crohn's and Colitis Canada; Hospital for Sick Children; University of Toronto; University of Alberta; Leona M. and Harry B. Helmsley Charitable Trust; Dalhousie University; Max Rady College of Medicine, University of Manitoba; BC Children's Hospital; Queen's University; Hebrew University of Jerusalem; McMaster University; McGill University Health Centre; McGill University; Cincinnati Children's Hospital Medical Center; Government of Ontario; Faculty of Medicine and Dentistry, University of Alberta; University of Miami","keywords":"Biology; Metabolomics; Crohn's disease; Disease; Computational biology; Bioinformatics; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003709033,0.0004413181,0.0004135847,0.0008653994,0.0002699441,0.0007586545,0.000140031,0.0003880328,0.0009650357],"category_scores_gemma":[0.0005498758,0.0002090184,0.0003365106,0.0008674672,0.0002170228,0.0002468374,0.0004620906,0.0003550161,0.0001105565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002732497,"about_ca_system_score_gemma":0.0001771972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002181028,"about_ca_topic_score_gemma":0.003569083,"domain_scores_codex":[0.9997781,0.0000484433,0.00001611513,0.00006882037,0.00003928816,0.00004926242],"domain_scores_gemma":[0.9997259,0.00004888387,0.0001267113,0.00002710365,0.00002385315,0.00004761097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002381386,0.0001040656,0.9356439,0.00006491512,0.000433586,0.0003229552,0.0001904818,0.0003175437,0.04894592,0.0001249358,0.0001606491,0.01130967],"study_design_scores_gemma":[0.0000110394,0.00009840247,0.9970742,0.000006722331,0.00008459968,0.0002679536,0.00007412197,0.0004788017,0.001557619,0.0001248958,0.0002167429,0.000004747153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979334,0.001032764,0.0003431791,0.00005785263,0.000003282376,0.000005445821,0.0003959173,0.000008537952,0.0002196329],"genre_scores_gemma":[0.9987476,0.0002737804,0.0003825351,0.00002753852,0.000005344969,0.000004248404,0.0003610507,0.000002998024,0.0001948758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002181028,"threshold_uncertainty_score":0.004336715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003154780622519858,"score_gpt":0.1973727274701107,"score_spread":0.1942179468475908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}