{"id":"W4414019364","doi":"10.1080/19490976.2025.2546998","title":"Metabolomics reveal distinct molecular pathways associated with future risk of Crohn’s Disease","year":2025,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; St. Paul's Hospital; University of Manitoba; Queen's University; BC Children's Hospital; Children's Hospital of Eastern Ontario; University of Ottawa; McGill University Health Centre; Centre Hospitalier Universitaire Sainte-Justine; University of British Columbia; University Health Network; Health Sciences Centre; Ontario College of Art and Design; Hospital for Sick Children; Université de Montréal; University of Alberta; University of Toronto; Princess Margaret Cancer Centre; University of Calgary; Mount Sinai Hospital","funders":"Temerty Faculty of Medicine, University of Toronto; Canadian Institutes of Health Research; Leonard M. Miller School of Medicine; Crohn's and Colitis Canada; Hospital for Sick Children; University of Toronto; University of Alberta; Leona M. and Harry B. Helmsley Charitable Trust; Dalhousie University; Max Rady College of Medicine, University of Manitoba; BC Children's Hospital; Queen's University; Hebrew University of Jerusalem; McMaster University; McGill University Health Centre; McGill University; Cincinnati Children's Hospital Medical Center; Government of Ontario; Faculty of Medicine and Dentistry, University of Alberta; University of Miami","keywords":"Biology; Metabolomics; Crohn's disease; Disease; Computational biology; Bioinformatics; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802768,0.000230183,0.0002161311,0.00005677016,0.0001029253,0.00002134757,0.0002527018,0.0001419399,0.00001374454],"category_scores_gemma":[0.0002408252,0.0002008112,0.0001749341,0.0001301672,0.0001448403,0.000005337102,0.0001511828,0.0001165958,0.000004356834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000238147,"about_ca_system_score_gemma":0.0002917916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009900717,"about_ca_topic_score_gemma":0.00005344328,"domain_scores_codex":[0.9988033,0.0001581573,0.0002568008,0.0003767031,0.0001124435,0.0002926329],"domain_scores_gemma":[0.9989638,0.00001238198,0.0001850307,0.0005325778,0.0001872356,0.0001190282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001734201,0.000344666,0.1232299,0.0001741399,0.0008746651,0.0004438702,0.00006229758,0.000199814,0.8653351,0.0011811,0.005403479,0.001016706],"study_design_scores_gemma":[0.0011801,0.0000370948,0.9133652,0.00007901994,0.0004735961,0.000001476287,0.00006281586,0.00002832801,0.08055115,0.0003379052,0.003572714,0.0003105351],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995389,0.001843572,0.0009500099,0.00006159826,0.0001315515,0.0002689958,0.0008194429,0.00002514486,0.0005106435],"genre_scores_gemma":[0.9982352,0.00009228563,0.0003430431,0.000209651,0.00007926552,0.00002645715,0.0004599672,0.0000284756,0.0005257169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7901353,"threshold_uncertainty_score":0.8188844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003154780622519858,"score_gpt":0.1973727274701107,"score_spread":0.1942179468475908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}