{"id":"W4414019836","doi":"10.1038/s41467-025-63564-2","title":"Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut Universitaire de Gériatrie de Montréal","funders":"National Institute on Aging; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Knut och Alice Wallenbergs Stiftelse; Servier; Siemens Healthineers; Skånes universitetssjukhus; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Parkinsonfonden; Greta och Johan Kocks stiftelser; Vetenskapsrådet; Eisai; GHR Foundation; Northern California Institute for Research and Education; Australian Government; Meso Scale Diagnostics; Cure Alzheimer's Fund; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Lunds Universitet; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health","keywords":"Tau pathology; Amyloid (mycology); Alzheimer's disease; Asymmetry; Pathology; Disease; Amyloid β; Neuroscience; Medicine; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004261224,0.0003479815,0.0002885817,0.0008740812,0.0003249767,0.0004397702,0.0002050818,0.0003368553,0.002622908],"category_scores_gemma":[0.001937012,0.0001263291,0.0002307862,0.0003934719,0.0003346533,0.0003267297,0.000413229,0.0002452713,0.0003466039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000155543,"about_ca_system_score_gemma":0.0001201899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001994999,"about_ca_topic_score_gemma":0.002184463,"domain_scores_codex":[0.9997926,0.00004346702,0.00002466286,0.00006608079,0.0000462333,0.00002686325],"domain_scores_gemma":[0.9989439,0.0001914672,0.0005180655,0.0001378833,0.00008957018,0.0001191872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009778941,0.00005290058,0.9744543,0.00002675849,0.0002094193,0.0008208305,0.0003614087,0.0002643695,0.01200575,0.0001847092,0.0003461113,0.01029535],"study_design_scores_gemma":[0.00000480269,0.0000423131,0.9979535,0.00000399665,0.00001851481,0.001030151,0.00006050463,0.0001696019,0.0003125195,0.0003032334,0.00009690481,0.000003784595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989649,0.0001751563,0.00015307,0.00002633848,0.000002836322,0.000002720701,0.0001320376,0.000004347668,0.0005386436],"genre_scores_gemma":[0.9995529,0.00005769139,0.00008304502,0.000009818498,0.000006122775,0.000003617663,0.0001423108,0.000003226303,0.0001412952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002622908,"threshold_uncertainty_score":0.008774459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029336403609552,"score_gpt":0.3578507483376258,"score_spread":0.3375573843015303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}