{"id":"W4414020224","doi":"10.3390/jcdd12090342","title":"Comparative Study on Cardiac Findings in Patients with Transthyretin Amyloidosis Before and After Treatment with a Transthyretin Silencer","year":2025,"lang":"en","type":"article","venue":"Journal of Cardiovascular Development and Disease","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Transthyretin; Silencer; Amyloidosis; Cardiac amyloidosis; Medicine; Internal medicine; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002015824,0.0003405118,0.0006582174,0.0001887479,0.00008345441,0.00004415003,0.00007474297,0.00006187548,0.000003214088],"category_scores_gemma":[0.00000961365,0.0002198783,0.0002565166,0.0001523215,0.00009094826,0.000017897,0.00002309314,0.00008712892,5.339084e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009892689,"about_ca_system_score_gemma":0.0002746346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006941881,"about_ca_topic_score_gemma":0.00003324716,"domain_scores_codex":[0.9985126,0.000138123,0.000337106,0.000388935,0.0003951302,0.0002281094],"domain_scores_gemma":[0.9993317,0.00001729104,0.00007939282,0.000219585,0.0001142978,0.0002377697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003774779,0.0009196374,0.9825734,0.00003204278,0.004497539,0.00008009507,0.001855932,0.00006323912,0.00001408349,0.000002400414,0.000022568,0.006164321],"study_design_scores_gemma":[0.008741991,0.002179041,0.983889,0.0001907497,0.001233262,0.000001666471,0.0009407454,7.535331e-7,0.001066559,0.000003623186,0.001509665,0.0002429479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937402,0.005163909,0.00006669268,0.000117806,0.0000381235,0.0007967107,0.00002121816,0.000003992202,0.00005133617],"genre_scores_gemma":[0.9988921,0.0004664321,0.0002882653,0.00007369473,0.00002125587,0.0001803943,0.00002088415,0.00001733288,0.00003967115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005921373,"threshold_uncertainty_score":0.8966378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005240923566013181,"score_gpt":0.2231230839833319,"score_spread":0.2178821604173188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}