{"id":"W4414020659","doi":"10.1111/acel.70207","title":"The Role of Selection for Function in Aging and Chronic Diseases: A Novel Evolutionary Perspective","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"Centre National de la Recherche Scientifique; Agence Nationale de la Recherche","keywords":"Pleiotropy; Biology; Organism; Selection (genetic algorithm); Evolutionary biology; Mechanism (biology); Adaptation (eye); Function (biology); Mutation Accumulation; Natural selection; Genetics; Phenotype; Neuroscience; Genome; Gene; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002942809,0.0007963326,0.001202085,0.001355242,0.001312936,0.003707947,0.001480734,0.002385151,0.002627042],"category_scores_gemma":[0.002503894,0.0002125991,0.0008211351,0.0008676879,0.009155735,0.005739126,0.00234496,0.002859061,0.0003023121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001682597,"about_ca_system_score_gemma":0.001136969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00146564,"about_ca_topic_score_gemma":0.001423365,"domain_scores_codex":[0.9990819,0.0003362075,0.00003555249,0.0003130671,0.0001306046,0.0001025446],"domain_scores_gemma":[0.9985693,0.0007298511,0.0001742318,0.0001276737,0.0001934359,0.0002054691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001003281,0.00006191187,0.01030003,0.0004578731,0.0001735259,0.0007516458,0.002587385,0.004084921,0.004793929,0.8826591,0.003011711,0.09101779],"study_design_scores_gemma":[0.00002487007,0.0002095585,0.01359831,0.0002279979,0.0001165514,0.001222621,0.001503352,0.008152011,0.0007197302,0.9167936,0.05733972,0.00009164403],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2064595,0.2655323,0.2549145,0.1893629,0.004055275,0.0001033487,0.0004351962,0.000323102,0.07881384],"genre_scores_gemma":[0.870043,0.06331686,0.04077423,0.01171131,0.005211262,0.00009147016,0.000175383,0.00008092015,0.008595487],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003707947,"threshold_uncertainty_score":0.01556331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00307505375239221,"score_gpt":0.2163122036623171,"score_spread":0.2132371499099249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}