{"id":"W4414024453","doi":"10.1101/2025.09.04.674347","title":"Epigenomic regulation of human oligodendrocyte myelination properties – relation to age and lineage","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Epigenomics; Lineage (genetic); Oligodendrocyte; Relation (database); Neuroscience; Biology; Genetics; Computer science; Gene; Myelin; DNA methylation; Central nervous system; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534971,0.00008004616,0.0002142069,0.0005017639,0.0001054707,0.0003057792,0.00007767168,0.0001314381,0.002109106],"category_scores_gemma":[0.0003204015,0.0000808866,0.0001628749,0.0008732263,0.00007251699,0.000132516,0.0001961636,0.0001426961,0.0004013456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000104338,"about_ca_system_score_gemma":0.0000725421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302337,"about_ca_topic_score_gemma":0.00126338,"domain_scores_codex":[0.9998693,0.00001504466,0.000008739826,0.00006455868,0.00001989508,0.00002237666],"domain_scores_gemma":[0.9997495,0.00006219542,0.0001011334,0.00002751191,0.00003662415,0.00002302555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001566941,0.0000399974,0.4856641,0.0002085468,0.000390306,0.0003498796,0.0003771963,0.0004098926,0.4800875,0.0002372037,0.001385799,0.02928258],"study_design_scores_gemma":[0.000002778701,0.00004915376,0.9891812,0.000007079292,0.00004663314,0.0002753129,0.00007043892,0.0002597406,0.007903692,0.00008210717,0.002116674,0.000005213848],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988326,0.001717363,0.0008439083,0.00003929991,0.000006550367,0.00000612968,0.008302842,0.00003002091,0.0007277481],"genre_scores_gemma":[0.9896897,0.0007029025,0.000621648,0.00004495978,0.00001051136,0.00002063838,0.007723283,0.00001831276,0.00116803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002109106,"threshold_uncertainty_score":0.0070557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03402246405312991,"score_gpt":0.2387722286325934,"score_spread":0.2047497645794635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}