{"id":"W4414024538","doi":"10.1002/cpt.70059","title":"<scp>GenoStaR</scp> : An R Package for Genotype to Star Allele Conversion for Major Cytochrome <scp>P450</scp> Family of Genes","year":2025,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; Myriad Genetics; Assurex Health","keywords":"Pharmacogenomics; Genotyping; Genotype; CYP2D6; Genetics; Allele; CYP2C19; Pharmacogenetics; Biology; CYP2C9; Haplotype; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004289126,0.003217837,0.002357243,0.001735644,0.0004628016,0.001995318,0.002430116,0.0009659629,0.05816456],"category_scores_gemma":[0.02003886,0.001402135,0.002963023,0.001657856,0.0008770261,0.001503216,0.00266138,0.002914203,0.03076613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006891737,"about_ca_system_score_gemma":0.002622639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004448371,"about_ca_topic_score_gemma":0.004967717,"domain_scores_codex":[0.9975728,0.001032401,0.0002179853,0.0005773455,0.0004108233,0.0001885631],"domain_scores_gemma":[0.9898062,0.007289445,0.001038371,0.0008803059,0.0007183029,0.0002673397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001609355,0.0001333336,0.02095114,0.004645861,0.002870531,0.001070152,0.0005716929,0.01501268,0.005694926,0.01043405,0.8463829,0.09062337],"study_design_scores_gemma":[0.002197054,0.0005984316,0.03301715,0.001151424,0.001461235,0.001982558,0.0002404453,0.1361049,0.01697659,0.04784736,0.7578787,0.000544164],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"software","genre_gemma":"software","genre_scores_codex":[0.01316385,0.001753827,0.2590874,0.001236919,0.0005293388,0.0008465977,0.2856969,0.4318627,0.005822525],"genre_scores_gemma":[0.1152904,0.002266899,0.3983329,0.003209379,0.0003870082,0.008436576,0.2312382,0.2296462,0.01119238],"genre_candidate":"software","genre_consensus":"software","teacher_disagreement_score":0.05816456,"threshold_uncertainty_score":0.1945798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1804791213810116,"score_gpt":0.4970048930810093,"score_spread":0.3165257716999977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}