{"id":"W4414026841","doi":"10.3389/fphar.2025.1651122","title":"Nasal cells as a bronchial cell surrogate for pre-clinical assessment of drug response in cystic fibrosis","year":2025,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; Hospital for Sick Children","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Cystic fibrosis; Medicine; Drug response; Drug; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002280306,0.0004574319,0.0007104009,0.0005780397,0.0005950939,0.001106858,0.0004080334,0.001028616,0.003295716],"category_scores_gemma":[0.002125388,0.0002570748,0.0004803881,0.000379035,0.0007801995,0.0005900644,0.0008424127,0.001422129,0.001465423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002408093,"about_ca_system_score_gemma":0.0005147973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009317296,"about_ca_topic_score_gemma":0.002146028,"domain_scores_codex":[0.9971412,0.0009140543,0.0003066403,0.0004172398,0.00103824,0.0001826585],"domain_scores_gemma":[0.9986889,0.0003732462,0.000153977,0.0002665866,0.000404592,0.0001128531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005612788,0.0001702018,0.01702832,0.0003791077,0.00003063243,0.0006551306,0.0006343939,0.0001965628,0.9685857,0.0003612154,0.0005840483,0.01081343],"study_design_scores_gemma":[0.0000465866,0.003161428,0.07900146,0.0002927829,0.00016689,0.003990893,0.001886624,0.002612531,0.8805715,0.0006553672,0.02754219,0.00007161179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8904216,0.01322121,0.07695159,0.001512364,0.0008712448,0.002230223,0.004310472,0.0004562459,0.01002498],"genre_scores_gemma":[0.9262899,0.004992088,0.05521761,0.001512617,0.000180049,0.002081857,0.004438723,0.0001372623,0.005149898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003295716,"threshold_uncertainty_score":0.01205957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241876621965393,"score_gpt":0.4197722289948848,"score_spread":0.4073534627752309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}