{"id":"W4414028524","doi":"10.1002/ehf2.15412","title":"Re-PERFUSE: Phase 1b Study of AZD3427, a Novel Relaxin Receptor Agonist, on Renal Perfusion in HFrEF Patients","year":2025,"lang":"en","type":"article","venue":"ESC Heart Failure","topic":"Pregnancy-related medical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"AstraZeneca","keywords":"Medicine; Renal function; Ejection fraction; Urology; Tolerability; Renal blood flow; Cardiology; Internal medicine; Placebo; Perfusion; Heart failure; Adverse effect; Kidney; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001759272,0.001631422,0.002579192,0.0003382009,0.0003463277,0.0008657,0.0007458683,0.001753663,0.004070166],"category_scores_gemma":[0.0009055384,0.0005378828,0.001453448,0.0002645996,0.0009139669,0.0008837134,0.000318983,0.002752098,0.0006558729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005102776,"about_ca_system_score_gemma":0.0009927636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026579,"about_ca_topic_score_gemma":0.002143871,"domain_scores_codex":[0.9995474,0.0002237873,0.000017667,0.00007120833,0.00003593332,0.0001039198],"domain_scores_gemma":[0.9994413,0.0001026882,0.0001054482,0.0000458766,0.00004775118,0.0002568816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8740855,0.04218077,0.001626002,0.0007599434,0.001076368,0.0001074223,0.0001225373,0.0008884703,0.0416369,0.0001586677,0.002231582,0.0351257],"study_design_scores_gemma":[0.6543755,0.3379599,0.00374652,0.00002322524,0.0003676678,0.00007578366,0.00002530755,0.0003828217,0.002009616,0.00008146388,0.0009313015,0.0000209735],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907256,0.003809276,0.000419132,0.0005710792,0.0001408232,0.001860354,0.001273834,0.0001075748,0.001092331],"genre_scores_gemma":[0.9874315,0.002373297,0.001640064,0.001491979,0.0004186975,0.002293231,0.001961903,0.00003448553,0.002354805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004070166,"threshold_uncertainty_score":0.01361603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205763172809691,"score_gpt":0.3454033166842063,"score_spread":0.3248269994032372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}