{"id":"W4414028524","doi":"10.1002/ehf2.15412","title":"Re-PERFUSE: Phase 1b Study of AZD3427, a Novel Relaxin Receptor Agonist, on Renal Perfusion in HFrEF Patients","year":2025,"lang":"en","type":"article","venue":"ESC Heart Failure","topic":"Pregnancy-related medical research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"AstraZeneca","keywords":"Medicine; Renal function; Ejection fraction; Urology; Tolerability; Renal blood flow; Cardiology; Internal medicine; Placebo; Perfusion; Heart failure; Adverse effect; Kidney; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008241461,0.0002689553,0.0006443742,0.0005863659,0.0001123539,0.00001588988,0.0002379105,0.0003533845,0.0006759366],"category_scores_gemma":[0.00272514,0.000223252,0.0001158656,0.001184194,0.0001313017,0.00008524967,0.0001918254,0.001541086,0.0001467442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339459,"about_ca_system_score_gemma":0.0005607945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003241868,"about_ca_topic_score_gemma":0.0002945417,"domain_scores_codex":[0.9965531,0.0002399497,0.0007397321,0.0006360536,0.001258918,0.0005722912],"domain_scores_gemma":[0.9981861,0.0003113778,0.00009116557,0.0007966907,0.0002695748,0.0003450858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01380112,0.1472318,0.1371176,0.001229612,0.0004332476,0.0003521879,0.01139483,0.00002990729,0.2100611,0.0005045242,0.3602631,0.1175809],"study_design_scores_gemma":[0.2746595,0.04996017,0.1218181,0.05763626,0.0004208502,0.00001451103,0.007361831,0.001588432,0.06660936,0.0001198133,0.4183705,0.001440706],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883455,0.0003166547,0.00001854593,0.007191596,0.0002404521,0.001928388,0.0000254198,0.00006538738,0.001868038],"genre_scores_gemma":[0.995506,0.00007176352,0.0007811286,0.000512682,0.00007441331,0.0001014374,0.00006769713,0.00003697682,0.002847901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2608584,"threshold_uncertainty_score":0.9103951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205763172809691,"score_gpt":0.3454033166842063,"score_spread":0.3248269994032372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}