{"id":"W4414028558","doi":"10.1101/2025.08.30.673288","title":"Dynamic fates of dietary antigen-specific T helper cells in a model of early life oral tolerance","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; University of Victoria; Canadian Allergy, Asthma and Immunology Foundation","keywords":"Oral tolerance; Immunology; Antigen; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002266743,0.0003908203,0.0003079814,0.0005023309,0.00018004,0.0003501793,0.0002776275,0.0004999302,0.001090969],"category_scores_gemma":[0.000126115,0.0001822361,0.0002774436,0.0001590125,0.000329924,0.000298604,0.0002534529,0.001185394,0.0003026518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000275712,"about_ca_system_score_gemma":0.0001854611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002430898,"about_ca_topic_score_gemma":0.0003790393,"domain_scores_codex":[0.9998071,0.00002718424,0.00001432604,0.00005068935,0.00004015916,0.00006059788],"domain_scores_gemma":[0.9997965,0.00002313815,0.00006469103,0.00002678165,0.00001599209,0.00007301674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005420352,0.0003074588,0.0008944285,0.00004195458,0.000003462672,0.0001503176,0.00006882003,0.0001160918,0.9960399,0.0001308528,0.00003390671,0.001670787],"study_design_scores_gemma":[0.0001653945,0.01259643,0.02080849,0.00004478389,0.0000706674,0.001302857,0.0005077207,0.003755652,0.9550856,0.0005242915,0.005104977,0.00003303918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970827,0.0005407982,0.001497417,0.00004045918,0.00002697156,0.00005093706,0.0001743398,0.00003418021,0.0005522034],"genre_scores_gemma":[0.9939897,0.0004865382,0.001957113,0.00006143932,0.00001621415,0.0001525895,0.0002440241,0.00001604816,0.003076311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090969,"threshold_uncertainty_score":0.003649652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680243291867837,"score_gpt":0.2199915998266955,"score_spread":0.2031891669080171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}