{"id":"W4414028793","doi":"10.1101/2025.09.04.674322","title":"Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Atrioventricular node; In vivo; Induced pluripotent stem cell; In vitro; Bridge (graph theory); Cell biology; Stem cell; Electrical conduction system of the heart; Chemistry; Biology; Anatomy; Medicine; Cardiology; Electrocardiography; Embryonic stem cell; Biotechnology; Biochemistry; Tachycardia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003699647,0.0006161225,0.0006751516,0.0005879923,0.0001750151,0.0002398247,0.0004210649,0.0004203281,0.000007723424],"category_scores_gemma":[0.00009057147,0.0005698597,0.0001278108,0.0009057775,0.0002249974,0.0002665566,0.000749158,0.00101811,0.000007714333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685695,"about_ca_system_score_gemma":0.0001640144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005825931,"about_ca_topic_score_gemma":0.000001739717,"domain_scores_codex":[0.9962133,0.0002738468,0.0006768876,0.00170544,0.0003840195,0.0007464857],"domain_scores_gemma":[0.9987434,0.00006571553,0.0002516835,0.0006831711,0.0000687372,0.0001872724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004390332,0.0001695905,0.0003559552,0.000308553,0.000003365869,0.0005452289,0.00001666638,0.0007432669,0.9977818,0.00001528834,0.00001532715,0.000001118348],"study_design_scores_gemma":[0.0006156552,0.00004452824,0.006424844,0.0003079321,0.00001527009,2.211558e-7,0.00000421501,0.002085547,0.9895674,4.541791e-7,0.0003311154,0.0006028122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967803,0.0004603039,0.00005957873,0.00009939688,0.001114914,0.001148492,0.00009543783,0.0002368499,0.00000467224],"genre_scores_gemma":[0.9987028,0.0005095396,0.00009413863,0.0003516625,0.00007756513,0.000183244,7.155295e-8,0.00004765291,0.00003334332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008214331,"threshold_uncertainty_score":0.9996753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.037686740766704,"score_gpt":0.2219736944708535,"score_spread":0.1842869537041495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}