{"id":"W4414035710","doi":"10.1016/s1470-2045(25)00351-1","title":"Metastases-directed therapy in addition to standard systemic therapy in oligometastatic castration-resistant prostate cancer in Canada (GROUQ-PCS 9): a multicentre, open-label, randomised, phase 2 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Nova Scotia Cancer Centre; Dalhousie University; Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec; McMaster University; Juravinski Cancer Centre; Trillium Health Centre; London Health Sciences Centre; CancerCare Manitoba; University Health Network; Princess Margaret Cancer Centre; Credit Valley Hospital; Centre hospitalier universitaire de Québec; Université du Québec en Outaouais; Université de Montréal; McGill University Health Centre; McGill University; Hôpital Charles-Le Moyne; Centre Hospitalier de l’Université de Montréal; Jewish General Hospital","funders":"Jewish General Hospital; Astellas Pharma Canada","keywords":"Medicine; Prostate cancer; Systemic therapy; Open label; Oncology; Randomized controlled trial; Internal medicine; Castration; Clinical trial; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001064463,0.001935098,0.002643579,0.0005021548,0.000645076,0.001035731,0.001255935,0.001620025,0.0089613],"category_scores_gemma":[0.001150817,0.000539903,0.001891608,0.0006704802,0.001688322,0.000742274,0.0005056088,0.003689454,0.0008829268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004330856,"about_ca_system_score_gemma":0.005729046,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.08947729,"about_ca_topic_score_gemma":0.2299077,"domain_scores_codex":[0.999459,0.0001841718,0.00001472702,0.0001176395,0.00006786736,0.0001564942],"domain_scores_gemma":[0.9993016,0.0001153793,0.0001005241,0.00002879476,0.00005830591,0.0003954198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9605613,0.005926755,0.0007321669,0.0007640738,0.001035098,0.0000412389,0.0001114071,0.0007801349,0.001721433,0.0001799486,0.002247901,0.02589851],"study_design_scores_gemma":[0.9154631,0.07785655,0.004339614,0.0000584544,0.0004707189,0.00003724616,0.00006043781,0.0005407171,0.0002228455,0.000148965,0.0007782626,0.00002311331],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834119,0.005644391,0.0004542018,0.00122913,0.0006120313,0.003016447,0.002154126,0.0001677597,0.003310077],"genre_scores_gemma":[0.9843419,0.003843972,0.001277353,0.00113716,0.0003054985,0.001436405,0.001793569,0.00003319229,0.005831042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9105227,"threshold_uncertainty_score":0.177913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0798744365701188,"score_gpt":0.4285014221654537,"score_spread":0.3486269855953349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}