{"id":"W4414036237","doi":"10.1080/03007995.2025.2558140","title":"Patient-reported efficacy of adjunctive brexpiprazole in major depressive disorder in a phase 4, open-label, interventional study","year":2025,"lang":"en","type":"article","venue":"Current Medical Research and Opinion","topic":"Treatment of Major Depression","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Global Affairs Canada; University of Toronto; University of Calgary; Translational Research in Oncology; University of Alberta","funders":"","keywords":"Medicine; Major depressive disorder; Open label; Adjunctive treatment; Psychiatry; Internal medicine; Clinical trial; Mood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002646377,0.001137122,0.00194786,0.0004574245,0.0004232367,0.0007958088,0.0007102509,0.00125427,0.003080696],"category_scores_gemma":[0.002152265,0.0004843728,0.001029001,0.0004124294,0.0007664998,0.001041468,0.0004063745,0.001876888,0.0006429679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005795849,"about_ca_system_score_gemma":0.000697779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003939656,"about_ca_topic_score_gemma":0.001053201,"domain_scores_codex":[0.9988419,0.0006056487,0.00009524199,0.0001624747,0.0001639575,0.0001307183],"domain_scores_gemma":[0.9984745,0.0003788009,0.0005404134,0.0001576788,0.0001615474,0.0002870122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7538694,0.1285563,0.01287104,0.001276139,0.001954478,0.0001708786,0.0005287681,0.0006809482,0.02310846,0.0001250742,0.001316741,0.07554181],"study_design_scores_gemma":[0.2849125,0.6690992,0.04068592,0.00005259517,0.0007398518,0.000113178,0.0001060591,0.0007367022,0.002119485,0.0001074152,0.001286799,0.00004031743],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950315,0.0004532671,0.0003183362,0.00008291406,0.00003198189,0.002577311,0.0006613035,0.00004971748,0.0007937156],"genre_scores_gemma":[0.9886523,0.0006244583,0.001622098,0.0003443719,0.0001537208,0.006386272,0.001108622,0.00001106701,0.001097087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003080696,"threshold_uncertainty_score":0.01399553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205843702297778,"score_gpt":0.5085594885769612,"score_spread":0.3879751183471835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}