{"id":"W4414039781","doi":"10.1055/s-0045-1810726","title":"Efficacy and safety of risankizumab in patients with moderate to severe crohn’s disease: Results from the one-year SEQUENCE open-label Long-term extension","year":2025,"lang":"en","type":"article","venue":"Zeitschrift für Gastroenterologie","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Crohn's disease; Sequence (biology); Term (time); Medicine; Crohn disease; Disease; Extension (predicate logic); Open label; Pediatrics; Internal medicine; Adverse effect; Computer science; Physics; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002988626,0.0007628312,0.002226749,0.0003433322,0.0004303002,0.001053033,0.0004967102,0.001184588,0.001455355],"category_scores_gemma":[0.001811634,0.0003801078,0.002327944,0.0003528607,0.001071034,0.001189958,0.0004136685,0.002850277,0.000466923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007813984,"about_ca_system_score_gemma":0.0009990494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008133895,"about_ca_topic_score_gemma":0.001112928,"domain_scores_codex":[0.9990206,0.0003910316,0.00008697878,0.0001677515,0.0001425643,0.0001910835],"domain_scores_gemma":[0.998195,0.0004650352,0.0004783281,0.0002304582,0.0001317455,0.0004994998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8819526,0.01149515,0.01152829,0.0005427422,0.001644647,0.0001040001,0.0002628833,0.00119716,0.01251476,0.00009609415,0.0006187532,0.0780429],"study_design_scores_gemma":[0.4028639,0.4814687,0.1050666,0.00008480254,0.002593602,0.0003058485,0.0001548294,0.001623888,0.003418883,0.0002124412,0.002102092,0.0001043856],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958822,0.002586326,0.0002573554,0.0001448081,0.00007100563,0.0002024018,0.0004094267,0.00002743943,0.0004191085],"genre_scores_gemma":[0.996539,0.0009838707,0.0004816574,0.0002431562,0.0001005205,0.0001701058,0.0007922927,0.00001143204,0.0006779233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002988626,"threshold_uncertainty_score":0.01580554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201572073681263,"score_gpt":0.2818752931054409,"score_spread":0.2617180857373146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}