{"id":"W4414041810","doi":"10.1055/s-0045-1810731","title":"Early and sustained improvement in patient-reported outcomes and biomarker concentrations with tulisokibart induction in patients with moderately to severely active ulcerative colitis: a post-hoc analysis from ARTEMIS-UC","year":2025,"lang":"en","type":"article","venue":"Zeitschrift für Gastroenterologie","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Biomarker; Population; Disease; MEDLINE; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002288326,0.0009244987,0.003163364,0.0003284981,0.0003685278,0.001119251,0.0005386472,0.0006622286,0.002094256],"category_scores_gemma":[0.00197842,0.0002878886,0.003554365,0.0004006239,0.0006705051,0.001001925,0.000792516,0.001806367,0.0002440734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005233363,"about_ca_system_score_gemma":0.0007240253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007675966,"about_ca_topic_score_gemma":0.001237177,"domain_scores_codex":[0.9984972,0.0006081051,0.0001131288,0.0002929724,0.0001331165,0.0003554909],"domain_scores_gemma":[0.9983052,0.0007260853,0.0003002612,0.0002329638,0.0001088312,0.0003266998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8147699,0.002532741,0.1419508,0.0003988958,0.008712553,0.0003063105,0.0002064977,0.0009563713,0.008434473,0.00007688314,0.0005850955,0.02106937],"study_design_scores_gemma":[0.01715977,0.1614835,0.801993,0.00006129793,0.01038948,0.0003003734,0.0004800747,0.002708139,0.003506189,0.0002039764,0.001600047,0.000114226],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998843,0.0004396371,0.0001683134,0.00003556006,0.00003635695,0.00003963679,0.0001990401,0.00001050981,0.0002279816],"genre_scores_gemma":[0.9988291,0.0001029223,0.0001427534,0.0000427249,0.00003398192,0.00006247055,0.0004154074,0.000004599658,0.0003661493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003163364,"threshold_uncertainty_score":0.01210195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005210702232710222,"score_gpt":0.2340370242418644,"score_spread":0.2288263220091542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}