{"id":"W4414048656","doi":"10.1021/acssynbio.5c00412","title":"Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut","year":2025,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Stalemate; Stepping stone; Plasmid; Reverse genetics; Zebrafish; Caenorhabditis elegans","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002893347,0.0001736418,0.000151206,0.00007883403,0.00006494239,0.0000191887,0.0003732033,0.0001465585,0.00004251933],"category_scores_gemma":[0.00005315532,0.0001305142,0.00006013006,0.000136636,0.00009430067,0.00000121617,0.0001089722,0.00009431787,0.00001074882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002478674,"about_ca_system_score_gemma":0.00004563977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001178817,"about_ca_topic_score_gemma":0.0001898094,"domain_scores_codex":[0.9988092,0.0001188849,0.0002610806,0.0003619153,0.00006280624,0.0003861395],"domain_scores_gemma":[0.9994028,0.00004029876,0.00003444596,0.0004699905,0.00002112699,0.00003131346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003543535,0.0001274379,0.01542951,0.0000348235,0.0000597965,0.000007191929,0.0001729508,0.0002547821,0.9666427,0.0020935,0.001434781,0.01370707],"study_design_scores_gemma":[0.001168989,0.000498397,0.04271792,0.00005184646,0.00006319982,0.0000521464,0.001369579,0.00007696209,0.5184451,0.001612768,0.433482,0.0004610453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775204,0.004210419,0.01153485,0.001603304,0.0003463854,0.0004991269,0.00001982089,0.00001411774,0.004251596],"genre_scores_gemma":[0.9975948,0.0003109779,0.0005760789,0.0008003199,0.0000790338,0.0001281704,0.00003447978,0.00001116139,0.000464964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4481976,"threshold_uncertainty_score":0.5322215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005607350851835564,"score_gpt":0.2960580125149966,"score_spread":0.2904506616631611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}