{"id":"W4414048656","doi":"10.1021/acssynbio.5c00412","title":"Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut","year":2025,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Stalemate; Stepping stone; Plasmid; Reverse genetics; Zebrafish; Caenorhabditis elegans","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290168,0.0003111971,0.0001436845,0.0001437539,0.0001332171,0.000308493,0.0002119971,0.0003534821,0.0007705064],"category_scores_gemma":[0.00024439,0.0002508127,0.0001885576,0.00009558949,0.0002936042,0.0003021386,0.0004834809,0.0004985026,0.0002957614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000268658,"about_ca_system_score_gemma":0.0001379135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002735482,"about_ca_topic_score_gemma":0.0005438334,"domain_scores_codex":[0.9998564,0.00001846097,0.000008940495,0.00003955803,0.00004731038,0.00002936697],"domain_scores_gemma":[0.9998202,0.00003551635,0.00007610219,0.00002362431,0.00001479274,0.00002979801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000171575,0.000005721819,0.00006449287,0.00001240506,0.000002018173,0.00002167275,0.00001156364,0.0001350062,0.9984244,0.0001820102,0.00002415025,0.00109946],"study_design_scores_gemma":[0.000003114199,0.00007204077,0.0003564937,0.000002227712,0.000003356966,0.00004233282,0.000005707828,0.001036868,0.9966567,0.00003391282,0.001783791,0.000003622981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9429802,0.000628061,0.05310145,0.0001441442,0.00003346285,0.00005390666,0.0001753152,0.0005017597,0.002381575],"genre_scores_gemma":[0.9638155,0.0005208686,0.03159645,0.00008177883,0.000009048417,0.00007473429,0.0002211942,0.0001136414,0.003566806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007705064,"threshold_uncertainty_score":0.002577603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005607350851835564,"score_gpt":0.2960580125149966,"score_spread":0.2904506616631611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}