{"id":"W4414051486","doi":"10.1182/bloodadvances.2024015427","title":"The lncRNA <i>ELDR</i> suppresses tumorigenicity of AML by interfering with DNA replication and chromatin accessibility","year":2025,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut de Readaptation Gingras Lindsay de Montreal; Institute for Research in Immunology and Cancer; McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Chromatin; DNA replication; Myeloid leukemia; Demethylase; Chromatin immunoprecipitation; Replication factor C; Proliferating cell nuclear antigen; Small interfering RNA; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003508491,0.000113214,0.0002333273,0.00003851327,0.0001350585,0.00003221895,0.0002140583,0.00003469615,0.000008615491],"category_scores_gemma":[0.0004354375,0.00006676848,0.0000261534,0.000257126,0.0003055281,0.0001905252,0.000131925,0.0001733923,6.822045e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000405208,"about_ca_system_score_gemma":0.0001397329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006450622,"about_ca_topic_score_gemma":0.0000651937,"domain_scores_codex":[0.9989348,0.00005236252,0.0002689842,0.0003493376,0.0002036173,0.0001908804],"domain_scores_gemma":[0.998718,0.0003274756,0.0001187601,0.0006484748,0.0001336464,0.00005370451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001174034,0.0003459682,0.2376576,0.001328605,0.0002875827,0.000009498311,0.0002878616,0.00000424037,0.6951289,0.0004276606,0.002284621,0.06106339],"study_design_scores_gemma":[0.001243735,0.0002601783,0.05346264,0.0002608341,0.00009052836,0.00001978317,0.000282539,0.0000911931,0.9352606,0.0003291702,0.00861996,0.00007882542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889454,0.006513913,0.0003388133,0.001209944,0.00002981139,0.0004441229,0.00001421398,0.00004168825,0.00246211],"genre_scores_gemma":[0.9971241,0.001225845,0.0008117676,0.00009142129,0.00002780949,0.00005976356,0.000009470299,0.000009010042,0.0006408494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2401317,"threshold_uncertainty_score":0.272274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006719221263422101,"score_gpt":0.2986539211420436,"score_spread":0.2919346998786215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}