{"id":"W4414053788","doi":"10.1021/acsomega.5c01294","title":"Application of Gene Editing Technology Based on Targeted Delivery Materials in TNBC","year":2025,"lang":"en","type":"review","venue":"ACS Omega","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Natural Science Foundation of Sichuan Province","keywords":"Genome editing; CRISPR; Cas9; RNA interference; Gene delivery; Genetic enhancement; Viral vector; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122774,0.0005552886,0.0006293575,0.001327625,0.0001662069,0.0005301971,0.0003964645,0.0006629918,0.001536505],"category_scores_gemma":[0.0001960574,0.0002635113,0.0003897205,0.0009972507,0.0001948728,0.0005826959,0.0003943321,0.0008111927,0.001017794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003687448,"about_ca_system_score_gemma":0.0004055537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006346367,"about_ca_topic_score_gemma":0.0007962115,"domain_scores_codex":[0.9998869,0.0000153074,0.00001043118,0.00002131685,0.00005114032,0.00001487154],"domain_scores_gemma":[0.9999565,0.00002002149,0.000007647101,0.000002005362,0.000009621554,0.000004166671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007287623,0.00009581611,0.0001719633,0.02269727,0.0001015369,0.0005243447,0.0001002868,0.001033131,0.05948497,0.01087673,0.01541019,0.8894309],"study_design_scores_gemma":[0.00001217706,0.0001652482,0.0006049321,0.001261701,0.00009931204,0.001698394,0.00003555821,0.0003354785,0.01899109,0.001482153,0.9752876,0.00002647734],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001255664,0.9928058,0.001479339,0.0001834805,0.0002191112,0.00001900239,0.0000437397,0.00003661116,0.003957169],"genre_scores_gemma":[0.005080529,0.9912039,0.001199111,0.0001876165,0.00007052591,0.00002290126,0.00005868947,0.000006817399,0.00216988],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001536505,"threshold_uncertainty_score":0.005140185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006817038113877607,"score_gpt":0.2989180032281172,"score_spread":0.2921009651142396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}