{"id":"W4414060599","doi":"10.1038/s41591-025-03958-3","title":"Perioperative nivolumab or nivolumab plus ipilimumab in resectable diffuse pleural mesothelioma: a phase 2 trial and ctDNA analyses","year":2025,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute; National Institutes of Health; Congressionally Directed Medical Research Programs; Johns Hopkins University; Mesothelioma Applied Research Foundation; American College of Radiology Imaging Network; U.S. Food and Drug Administration; Bristol-Myers Squibb; ECOG-ACRIN Cancer Research Group; U.S. Department of Defense","keywords":"Nivolumab; Ipilimumab; Perioperative; Clinical endpoint; Progressive disease; Phases of clinical research; Neoadjuvant therapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001564565,0.001352821,0.001391569,0.0002916772,0.0002384332,0.0008759646,0.0005479604,0.001082383,0.001789325],"category_scores_gemma":[0.0007360805,0.000459261,0.00121033,0.0002135106,0.000541898,0.0006406127,0.0003094067,0.002519293,0.0004566355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000606751,"about_ca_system_score_gemma":0.001004099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004023987,"about_ca_topic_score_gemma":0.001206927,"domain_scores_codex":[0.9996573,0.0001623676,0.00002246942,0.00006144078,0.00002968751,0.00006676766],"domain_scores_gemma":[0.9996836,0.00004998157,0.00006137422,0.00003396784,0.0000251468,0.0001459878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7629575,0.05359538,0.003680618,0.001055574,0.001306703,0.0002145836,0.0002100823,0.002303753,0.05704426,0.0003336445,0.002874136,0.1144239],"study_design_scores_gemma":[0.5198544,0.462427,0.006027121,0.00006820049,0.0005938523,0.0001872621,0.0000480441,0.001484127,0.005840177,0.0003491851,0.003088066,0.00003258208],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936127,0.002463859,0.0004299754,0.0003249118,0.000156731,0.001410372,0.0004255862,0.00005098247,0.001124923],"genre_scores_gemma":[0.9890609,0.002100086,0.00142877,0.0007856145,0.0001872499,0.002709424,0.001244785,0.00002205698,0.002461308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001789325,"threshold_uncertainty_score":0.008274317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.037748315618624,"score_gpt":0.436238927607337,"score_spread":0.398490611988713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}