{"id":"W4414066839","doi":"10.1080/09537104.2025.2555197","title":"Talin autoinhibition is required for normal hemostasis","year":2025,"lang":"en","type":"article","venue":"Platelets","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Integrin; Focal adhesion; Clot retraction; Platelet; Extracellular matrix; Platelet adhesiveness; Platelet activation; Hemostasis; Cell adhesion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150337,0.0002248053,0.0002199766,0.0002380639,0.0002434291,0.0003646643,0.0002264277,0.0003096593,0.001552225],"category_scores_gemma":[0.000214563,0.00009973563,0.0001782885,0.0001329965,0.0002477648,0.000151049,0.0002871874,0.000444784,0.0005216333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003098725,"about_ca_system_score_gemma":0.0002783349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006566284,"about_ca_topic_score_gemma":0.0006441929,"domain_scores_codex":[0.9997969,0.0000188379,0.00001846932,0.00003469668,0.00008764813,0.00004346745],"domain_scores_gemma":[0.9998078,0.00002112578,0.0000670715,0.00001426936,0.00002010863,0.00006966641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009866972,0.00001289396,0.000548669,0.0000272338,0.000008172766,0.0003319547,0.00001644436,0.0001094193,0.9955198,0.0004411497,0.0001900496,0.002695616],"study_design_scores_gemma":[0.00003436377,0.0001539017,0.04226874,0.00001707332,0.00003329043,0.002954284,0.00005603948,0.002907761,0.9392208,0.0006463112,0.01168847,0.00001886509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858288,0.002700372,0.006655705,0.0002895926,0.00006325774,0.00002274746,0.0005358157,0.0003192763,0.003584479],"genre_scores_gemma":[0.9963731,0.000413017,0.0009772333,0.00005977585,0.00001491908,0.00001297444,0.0002830215,0.00003132304,0.001834625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001552225,"threshold_uncertainty_score":0.005192697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871527488250761,"score_gpt":0.2995700245872531,"score_spread":0.2808547497047454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}