{"id":"W4414066839","doi":"10.1080/09537104.2025.2555197","title":"Talin autoinhibition is required for normal hemostasis","year":2025,"lang":"en","type":"article","venue":"Platelets","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Integrin; Focal adhesion; Clot retraction; Platelet; Extracellular matrix; Platelet adhesiveness; Platelet activation; Hemostasis; Cell adhesion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006714543,0.0001367149,0.00027444,0.0001094999,0.0001075963,0.0000185444,0.00003964221,0.0001095028,0.0001545127],"category_scores_gemma":[0.00004735912,0.0001221832,0.0001217997,0.0001695546,0.00002646894,0.00008352254,0.00001979482,0.00006600006,0.00008681978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006187285,"about_ca_system_score_gemma":0.00007450509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002874538,"about_ca_topic_score_gemma":0.000008999734,"domain_scores_codex":[0.999172,0.000007311789,0.0002039131,0.000241056,0.0001138783,0.0002617901],"domain_scores_gemma":[0.9995964,0.00004997048,0.00004364649,0.0001795876,0.00006400319,0.00006646044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00464346,0.002828202,0.01096839,0.001373313,0.00220916,0.002662043,0.001233772,0.00001679874,0.03864721,0.005524905,0.4281412,0.5017515],"study_design_scores_gemma":[0.03336932,0.001403988,0.01653969,0.0009029909,0.001083357,0.0005927965,0.000248652,0.004563288,0.4670186,0.01233792,0.4611133,0.0008261008],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783957,0.0004386509,0.0006886814,0.005035216,0.0002006607,0.0006749858,0.0001061238,0.0001089317,0.01435107],"genre_scores_gemma":[0.9889697,0.00004997419,0.001354576,0.002396086,0.00003541588,0.00007707981,0.0003139881,0.00001615535,0.00678697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5009254,"threshold_uncertainty_score":0.4982485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871527488250761,"score_gpt":0.2995700245872531,"score_spread":0.2808547497047454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}